Dynamics of morphological lesions in the course of contact dermatitis induced in mice by sodium lauryl sulphate

• Autorzy: Kapusniak V
• Języki publikacji: EN

Abstrakty

EN

The present study is aimed at the determination of the character and intensity of morphological lesions in the skin, subjected to action of sodium lauryl sulphate as well as establishing, and if yes, to which extent the dermal process induced by primary chronic irritant, affects the reaction to secondary application of the damaging agent. The experiments were conducted on 24 white male mice of the inbred Balb/c strain. Surface of hairy skin (approximately 1 cm²), in the lumbo-dorsal region, was subjected to the action of sodium lauryl sulphate. The studies demonstrated differences in the intensity of the reaction not only among individual groups of experimental animals or individual animals within the group, but also between neighbouring sites in the skin of the same individual. Both the extent of thickening of epidermis and intensity of its keratinisation differed significantly between individual fields of the same section. In vicinity of necrotic regions, the areas were noted in which the epidermis underwent slight hypertrophy only or was almost unaltered, comparable to the control.

Słowa kluczowe

EN

skin; mouse; contact dermatitis; mice; irritant contact dermatitis; sodium lauryl sulphate

• Wydawca: -
• Czasopismo: Bulletin of the Veterinary Institute in Puławy
• Rocznik: 2007
• Tom: 51
• Numer: 1
• Opis fizyczny: p.155-160 fig,.ref.

Twórcy

autor

Kapusniak V

• University of Environmental and Life Sciences, 50-375 Wroclaw, Poland

Bibliografia

• 1. Alberts B., Bray D., Johnson A., Lewis J., Raff M., Roberts K., Walters P.: Principles of cell biology. Introduction to molecular biology. PWN, Warszawa 1999.
• 2. Effendy I., Maibach H.I.: Surfactants and experimental irritant contact dermatitis. Contact Dermatitis 1995, 33, 217-255.
• 3. Effendy I., Loffler H., Maikach H.I.: Epidermal cytokines in murine cutaneous irritant responses. J Appl Toxicol 2000, 4, 335-341.
• 4. Freeman S., Maibach H.: Study of irritant contact dermatitis produced by repeat patch test with sodium lauryl sulfate and assessed by visual methods, transepidermal water loss, and laser Doppler velocimetry. J Am Acad Dermatol 1988, 3, 496-502.
• 5. Gomori G.: The histochemistry of esterases. Int Rev Cytol 1952, 1, 323-335.
• 6. Hunziker T., Brand C.U., Kapp A., Waelti E.R., Braathen L.R.: Increased levels of inflammatory cytokines in human skin lymph derived from sodium lauryl sulphate-induced contact dermatitis. Br J Dermatol 1992, 3, 254- 257.
• 7. Kapuśniak V., Houszka M.: Structural and functional disturbances in skin subjected to action of Domestos preparation. Acta Sci Pol Seria Med Vet 2002, 1, 31-42.
• 8. Krasteva M., Kehren J., Ducluzeau M.T., Sayag M., Cacciapuoti M., Akiba H., Descotes J., Nicolas J. F.: Contact dermatitis. I. Pathophysiology of contact - sensitivity. Europ J Dermatol 1999, 9, 65-77.
• 9. Krawiec D.R., Gaafar S.M.: A comparative study of allergic and primary irritant contact dermatitis with dinitrochlorobenzene (DNCB) in dogs. J Invest Dermatol 1975, 2, 246-251.
• 10. Kondo S., Pastore S., Shivji G.M., McKenzie R.C., Sauder D.N.: Characterization of epidermal cytokine profiles in sensitization and elicitation phases of allergic contact dermatitis as well as irritant contact dermatitis in mouse skin. Lymphokine Cytokine Res 1994, 13, 367- 375.
• 11. Levin C.Y., Maibach H.I.: Irritant contact dermatitis: is there an immunologic component? Inter Immunopharmacol 2002, 2, 183-189.
• 12. Morrison R.T., Boyd R.N.: Organic chemistry. Ed. PWN, Warszawa 1996.
• 13. Ploton D., Menager M., Jeanesson P., Himber G., Piegon F., Adnett J.J.: Improvement in the staining and in the visualization of argyrophilic proteins of nucleolar organizer regions at the optical level. Histochem J 1986, 18, 5-14.
• 14. Scott D.W., Miller W.H., Griffin C.E.: Small animal dermatology. Ed. Muller&Kirk's, Philadelphia, Pennsylvania 2001.
• 15. Walters K.A., Bialik W., Brain K.R.: The effects of surfactants on penetration across the skin. Int J Cosm Sci 1993, 15, 260-270.
• 16. Willis C.M., Young E., Brandon D.R., Wilkinson J.D.: Immunopathological and ultrastructural findings in human allergic and irritant contact dermatitis. Br J Dermatol 1986, 3, 305-316.
• 17. Willis C.M., Stephens C.J., Wilkinson J.D.: Epidermal damage induced by irritans in man: a light and electron microscopic study. J Invest Dermatol 1989, 5, 695-699.
• 18. Willis C.M., Stephens C.J., Wilkinson J.D.: Differential effects of structurally unrelated chemical irritants on the density of proliferating keratinocytes in 48 h patch test reactions. J Invest Dermatol 1992, 99, 449-453.