EN
There has been a worldwide increase in the prevalence of allergy. Parasite infections may have a varied influence on the outcome of allergic reactions. Of particular interest is the possibility that helminth infections may lessen the intensity of allergy symptoms. This may occur due to the immune regulatory network evoked by helminthes decreasing allergy through the action of regulatory T lymphocytes and cytokines such as IL-10 and TGF-β. The authors of the article discuss the latest research results in this field as well as laboratory studies describing the phenomena. The article also describes multiple mechanisms which may be utilized by helminths to mediate the suppression of allergy, and which involve regulatory lymphocytes and cytokines, helminthic molecules and polyclonal IgE.