Wplyw Nalcromu [sodium cromoglycate] na przebieg jelitowej fazy wlosnicy u myszy

• Autorzy: Karmanska K , Michalska Z. , Mielczarek J. , Slaska B. , Stefaniak E.
• Języki publikacji: PL

Abstrakty

EN

The influence of Nalcrom (sodium cromoglycate) on the cource of the intestinal phase of trichinellosis in mice was investigated. The animals infected with 200 Trichinella spiralis larvae were treated with Nalcrom between 7-20 or 3-20 days after infection (d.a.i.). The drug was administered in two doses: 0,6 or 1, 7 mg/mouse/day. In the all groups of animals received Nalcrom higher number of mast cells and eosinophilis than in the control groups was observed. These results are the opposite of those obtained with Nalcrom in ulcerative colitis in man.

Słowa kluczowe

PL

fazy rozwojowe; wlosnica; choroby inwazyjne; wlosien krety; zwierzeta doswiadczalne; Trichinella spiralis; parazytologia; Nalcrom; myszy; nicienie; pasozyty; Trichinellidae

• Wydawca: -
• Czasopismo: Wiadomości Parazytologiczne
• Rocznik: 1992
• Tom: 38
• Numer: 3-4
• Opis fizyczny: s.135-141, rys.,tab.,bibliogr.

Twórcy

autor

Karmanska K

• Instytut Parazytologii PAN, Wroclaw

autor

Michalska Z.

autor

Mielczarek J.

autor

Slaska B.

autor

Stefaniak E.

Bibliografia

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• COX J. S. C. 1967. Disodium cromoglycate (FPL 670) ,,Intal" a specific inhibitor of reagnic antibody-antigen mechanisms. Nature 216: 1328-1329.
• DAVIES S. E. 1968. Effect of disodium cromoglycate on exercise-induced asthma. Br. Med. J. 3: 593-594.
• HEATLEY R. V., CALCRAFT B. J., RHODES J., OWEN E., EVANS B. K. 1975. Disodium cromoglycate in the treatment of chronic proctitis. Gut 16: 559-563.
• KARMAŃSKA K., MICHALSKA Z., MIELCZAREK J., ŚLĄSKA B. 1990. An attempt at modifying immunopathological changes in the muscles of mice by infection with Trichinella spiralis larvae of identical age. Acta Parasitol. Pol. 35: 167-172.
• MANI V., LLOYD G., GREEN F. H. Y., FOX H., TURNBERG L. A. 1976. Treatment of ulcerative colitis with oral disodium cromoglycate. Lancet 79575: 439-441.
• - ., - ., - ., - ., - . 1977. Morphological changes in the rectal mucosa in patients with ulcerative colitis treated with disodium cromoglycate. Gastroenterology 72: 1093.
• MICHALSKA Z., KARMAŃSKA K. 1976. Influence of inhibition of degranulation of mast cells by Intal (disodium cromoglycate) on the course oftrichinellosis in mice. Acta Parasitol. Pol. 14: 69-80.
• THOMPSON D., S., EVANS D. P. 1973. Inhibition of immediate hypersensivity reaction by disodium cromoglycate. Clin. Expl. Immunol. 13: 537-544.