Worsening of long-term myocardial function after successful pharmacological pretreatment with cyclosporine

• Autorzy: Laudi S. , Weimann J. , Haschke M. , Trump S. , Schmitz V. , Christians U. , Kaisers U. , Steudel W.
• Języki publikacji: EN

Abstrakty

EN

Pretreatment with cyclosporine (CsA) decreases infarct size 24h after myocardial ischemia/reperfusion (I/R). The goal of this study was to determine effects of CsA pretreatment on long-term cardiac function after I/R-injury. Rats were randomly assigned to group1: vehicle-only, group2: CsA-5mg/kg/day, and group3: CsA-12.5mg/kg/day given orally for three days prior to I/R-injury (30 min of left anterior descending coronary artery occlusion). Post-I/R survival and cardiac function were evaluated 14 days after I/R-injury by echocardiography and invasive hemodynamic measurements. Rats with I/R-injury showed increased left ventricular pressure (LVEDP) compared to rats without I/R-injury (p<0.005). Although CsA initially decreased infarct size, no differences of LVEDP were seen 14 days after I/R-injury (vehicle: 21.2±8.9 mmHg, CsA-5mg/kg/day: 21.5±0.7 mmHg, CsA-12.5mg/kg/day: 20.5±9.4 mmHg). Ejection fraction and fractional shortening were decreased compared to baseline, but showed no differences between groups. On day 14, a dose-dependent increase in left ventricular end diastolic diameter was seen (p<0.001). CsA pretreatment was associated with a dose-dependent decrease in post-I/R-survival (vehicle: 56%, CsA-5mg/kg/day: 32%, CsA-12.5mg/kg/day: 16%; p=0.017). CsA pretreatment did not improve long-term cardiac function despite decreased infarct size 24h after I/R-injury, but increased post-I/R mortality significantly. Poor cardiac function after CsA pretreatment might be caused by left ventricular dilation.

Słowa kluczowe

EN

ischaemia-reperfusion; cyclosporin; preconditioning; long-term myocardial function; myocardial infarction

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 2007
• Tom: 58
• Numer: 1
• Opis fizyczny: p.19-32,fig.,ref.

Twórcy

autor

Laudi S.

• University of Leipzig Medical Faculty, Liebigstrasse 20, 04103 Leipzig, Germany

autor

Weimann J.

autor

Haschke M.

autor

Trump S.

autor

Schmitz V.

autor

Christians U.

autor

Kaisers U.

autor

Steudel W.