Asymmetry in nucleotide composition of sense and antisense strands as a parameter for discriminating open reading frames as protein coding sequences

• Autorzy: Cebrat S , Dudek M R , Rogowska A
• Języki publikacji: EN

Abstrakty

EN

Coding properties of yeast chromosomes were analysed and a strong asymmetry was found in nucleotide composition of sense and antisense strands. This property generates two very simple parameters - [A]/[T] and [G]/[C] of the sense strand - which could be used for discrimination of open reading frames as coding sequences with very high, statistically described level of significance. The paper contains a description of the method of ellipse of concentration in the two parameter space, which can close coding sequences inside, leaving a big fraction of noncoding sequences outside the ellipse.

Słowa kluczowe

EN

concentration ellipse; yeast chromosome; DNA asymmetry; coding function; open reading frame; nucleotide composition; Saccharomyces cerevisiae

• Wydawca: -
• Czasopismo: Journal of Applied Genetics
• Rocznik: 1997
• Tom: 38
• Numer: 1
• Opis fizyczny: p.1-9,fig.

Twórcy

autor

Cebrat S

• Institute of Microbiology, Wroclaw University, Przybyszewskiego 63-77, 51-148 Wroclaw, Poland

autor

Dudek M R

• Institute of Theoretical Physics, Wroclaw University, Przybyszewskiego 63-77, 51-148 Wroclaw, Poland

autor

Rogowska A

• Institute of Microbiology, Wroclaw University, Przybyszewskiego 63-77, 51-148 Wroclaw, Poland

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