EN
The studies were carried out on 8 horses including two controls. Three nimals were given E. coli endotoxin twice at 24-hour intervals intravenously in a dose of 1.0 (ig/kg of body weight. The other three received the endotoxin 3 times in doses of 0.2 pg and 0.1 pg (after 3 hours) and 0.2 pg after 24 hours. In all six horses the signs of endotoxaemia of a different extent were observed. In the first group (3 horses) only insignificant statistical alterations were noticed regarding blood coagulation indices, while in the second group significant disturbances were found, i.d. a decrease in the number of thrombocytes, an increase of fibrinogen concentrations, the prolongation of the prothrombin and, in some animals, also of coalin-kep- halin times and a drop of AT III activity that indicate the occurrence of DIC syndrome.