Up-regulation of spermidine-spermine N1-acetyltransferase [SSAT] expression is a part of proliferative but not anabolic response of mouse kidney

• Autorzy: Dudkowska M. , Stachurska A. , Grzelakowska-Sztabert B. , Manteuffel-Cymborowska M.
• Języki publikacji: EN

Abstrakty

EN

A differential expression pattern of spermidine/spermine N1-acetyltransferase (SSAT), the enzyme critical to proper homeostasis of cellular polyamines, is reported in mouse kidney undergoing hyperplasia and hypertrophy. We have shown that SSAT activity and SSAT mRNA are significantly induced by antifolate CB 3717 and folate that evoke a drug-injury-dependent hyperplasia. In contrast, SSAT activity is down-regulated in the testosterone-induced hypertrophic kidney, while SSAT mRNA is positively controlled by this androgen. Catecholamine depletion evoked by reser- pine drastically decreases the folate-induced activity of «S-adenosylmethionine decar- boxylase (AdoMetDC), which limits polyamine biosynthesis, but has no effect on SSAT activity augmented by CB 3717. Our results document that the increased SSAT expression solely accompanies the proliferative response of mouse kidney, and sug­gest the importance of post-transcriptional regulation to the control of SSAT activity in both hyperplastic and hypertrophic experimental models.

Słowa kluczowe

EN

polyamine biosynthesis; spermine; mice; polyamine homeostasis; folic acid; reserpine; N1-acetyltransferase; proliferative response; polyamine metabolism; mouse; hyperplasia; ornithine decarboxylase; kidney; S-adenosylmethionine decarboxylase; anabolic response; testosterone; spermidine

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2002
• Tom: 49
• Numer: 4
• Opis fizyczny: p.969-977,fig.

Twórcy

autor

Dudkowska M.

• Polish Academy of Sciences, L.Pasteura 3, 02-093 Warsaw, Poland

autor

Stachurska A.

autor

Grzelakowska-Sztabert B.

autor

Manteuffel-Cymborowska M.

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