The study was performed on 110 great saphenous veins in human foetuses of both sexes aged 9 to 37 weeks. The earliest well-shaped valves were observed in foetuses aged 13 weeks. In these foetuses the number of valves varies from 2 to 7. Consecutive microscopic sections revealed that the developing valves at their origin present thickening of the endothelium which is continuous into the cusps of the valves. The bicuspid cusps are crescent-shaped and both surfaces are lined by endothelium.
1. Bochenek A, Reicher M (1993) Anatomia człowieka. T. 3, PZWZ, Warszawa 409–415.
2. Basmajian JV (1952) The distribution of valves in the femoral, external iliac and common iliac veins and their relationship to varicose veins. Surg Gynecol Obsted, 95: 537–542.
4. Czarniawska-Grzesińska M, Bruska M (1998) Distribution, intervalvular distances, and height of venous valves in the great saphenous vein in human fetuses. Folia Morphol, 57: 18.
5. Czarniawska-Grzesińska M, Bruska M (2002) Development of valves in the small saphenous vein in human fetuses. Folia Morphol, 61: 37–42.
6. Hoave MC, Nicolaides AN, Miles CR, Shull K, Jury RP, Needham T, Dudley HAF (1982) The role of primary varicose veins in venous ulceration. Surgery, 92: 450–453.
7. Kampmeier OF, La Fleur Birch C (1926) The origin and development of the venous valves, with particular reference to the saphenous district. Am J Anat, 38: 451–499.
8. Ludbrook J (1962) Functional aspect of the veins of the leg. Am Heart J, 64: 706–713.
9. Marinov G (1974) Anatomical features of valves of the small saphenous vein. Folia Morphol, 22: 23–25.
10. Powell T, Lynn RB (1951) The valves of the external iliac, femoral and upper third of the popliteal veins. Surg Gynecol Obstet, 92: 453–455.