Z-RNA. The synthesis of 2'-O-[13C]methyl- and 5-methyl-analogs of ribo-CGCGCG

• Autorzy: Biala E. , Milecki J. , Kowalewski A. , Popenda M. , Antkowiak W.Z. , Adamiak R.W.
• Języki publikacji: EN

Abstrakty

EN

Chemical synthesis of 2'-0-[13C methyl-rCGCGCG and 5-methyl-rCGCGCG using support-aided phosphoramidite method is presented. 2'-0-Methyl guanosine derivative was separated from its 3'-0-methyl counterpart using transient 5',3'-0-silylation with l,3-dichloro-l,l,3,3-tetraisopropyldisiloxane (Markiewicz reagent). The hexamers were obtained in a purity suitable for NMR studies.

Słowa kluczowe

EN

phosphoramitid method; chemical synthesis; 2'-O-[13C]methyl-rCGCGCG; 5-methyl-rCGCGCG

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1993
• Tom: 40
• Numer: 4
• Opis fizyczny: p.521-530,fig.

Twórcy

autor

Biala E.

• Polish Academy of Sciences, Z. Noskowskiego 12-14, 61-704 Poznan, Poland

autor

Milecki J.

autor

Kowalewski A.

autor

Popenda M.

autor

Antkowiak W.Z.

autor

Adamiak R.W.

Bibliografia

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