EN
A quaternary ammonium salt, dodecyloxycarboxymethyl N, N, N - trimethyl ammonium chloride (IM), inhibits glucose-stimulated proton extrusion in yeast cells. The IM-resistant mutant (IMR) and pmal mutant are less sensitive to this inhibition. The inhibition of amino acids uptake by IM depends on repressed or derepressed conditions. IM treatment of yeast cells leads to a change of internal pH in a quinacrine fluorescence test.