Signalling pathways mediating anti-apoptotic action of neurotrophins

• Autorzy: Hetman M , Xia Z.
• Języki publikacji: EN

Abstrakty

EN

Neurotrophins promote survival and suppress apoptosis in many populations of neurons. Currently, phosphatidylinositol-3 kinase (PI-3K) is recognized as the main mediator of this protective effect. However, most of the data collected so far on the anti-apoptotic signaling of neurotrophins were obtained using trophic withdrawal paradigms. Recent data from our and other groups indicate that extracellular-signal-regulated kinase 1/2 (Erk1/2) may play a critical role in suppressing neuronal apoptosis triggered by cellular damage. Thus, it appears that either Erk1/2 or PI-3K, depending on the nature of the death-inducing stimulus, can mediate anti-apoptotic signaling of neurotrophins. In this review, we discuss the contribution of Erk1/2 and PI-3K to neuroprotection by neurotrophins. We also present data suggesting possible mechanisms by which these pathways might suppress neuronal death.

Słowa kluczowe

EN

phosphorylation; brain-derived neurotrophic factor; signal transduction; extracellular-signal-regulated kinase; oxidative stress; neuron; glycogen synthase kinase 3beta; neurotrophin; cell damage; neuroprotection; apoptosis; DNA; nerve growth factor; phosphatidylinositol 3-kinase

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2000
• Tom: 60
• Numer: 4
• Opis fizyczny: p.531-545,fig.

Twórcy

autor

Hetman M

• University of Washington, Seattle, USA, WA98195-7234

autor

Xia Z.

Bibliografia

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