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2008 | 11 | 1 |

Tytuł artykułu

Comparative activities of semicarbazide-sensitive amine oxidase [SSAO] in five domestic species

Autorzy

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
Semicarbazide-sensitive amine oxidase (SSAO) activity was measured spectrophotometrically using benzylamine as a substrate, in the serum of healthy males and females of horses, camels, cattle, sheep and goats. The animals were born and raised in the same area, and the blood collection was made on the same day to avoid variations. Also the concentrations of protein and copper were measured in the same samples. There were no significant gender-related differences in SSAO activity between the tested animals regardless of species. Activities of SSAO in either male or female of horse were significantly different (p < 0.05) from the remaining tested animals. The highest activities (expressed as μmole of benzaldehyde production/mg protein/hr) were found in horses (9.592 and 9.458), followed by camels (3.226 and 2.407), cattle (1.014 and 1.648), goat (0.750 and 0.572) and sheep (0.435 and 0.244). Insignificant higher activities of SSAO were noted in all males of the tested animals compared to that in females except in cattle. The results suggest that horses are endowed with a very high activity of this enzyme amounting to 3-21 times higher than that found in large and small ruminants. There were no significant differences between the levels of protein and copper in either sex of all the tested species.

Wydawca

-

Rocznik

Tom

11

Numer

1

Opis fizyczny

p.63-66,fig.,ref.

Twórcy

  • College of Agriculture and Veterinary Medicine, Al-Qassim University, Burydaha, Saudi Arabia

Bibliografia

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  • Benedetti MS, Tipton, KF, Whomsley R (2007) Amine oxidases and momooxygenases in the in vivo metabolism of xenobiotic amines in humans. Funda Clin Pharmacol 21: 467-479
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  • Boomsma F, Hut H, Bagghoe U, van der Houwen A, van den Meiracker A (2005) Semicarbazide-sensitive amine oxidase (SSAO): from cell to circulation. Med Sci Monit 11: RA122-126.
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  • El Sheikh HA, Ali BH, Hassan T, Homeida AM (1986) The cytochromes P-450 concentrations in microsomes of liver, kidney and duodenal mucosa of the camel, sheep and goat. Vet Hum Toxicol 28: 527-529.
  • Evenson M (1988) Measurement of copper in biological samples by flame or electrothermal atomic spectrometry. Method Enzymolo 158: 351-357.
  • Helferich WG, Silva MH, Flueck WT, Hammock BD, Shull LR (1987) Xenobiotic biotransformation in livers and lungs of adult black-tailed deer: comparison with domes­tic goat and sheep. Comp Biochem Physiol C 88: 145-149.
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  • Matyus P, Dajka-Halasz B, Foldi A, Haider N, Barlocco D, Magyar K (2004) Semicarbazide-sensitive amine oxidase: current status and perspectives. Curr Med Chem 11: 1285-1298.
  • Obata T (2002) Semicarbazide-sensitive amine oxidase (SSAO) in the brain. Neurochem Res 27: 263-268.
  • O’Sullivan J, Unzeta M, Healy J, O’Sullivan MI, Davey G, Tipton KF (2004) Semicarbazide-sensitive amine oxidases: enzymes with quite a lot to do. Neurotoxicology 25: 303-315.
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  • Rohlf FJ (2001) NTSYpc, Version 2.11T, Applied Biostas- tics Inc., USA.
  • Rucker RB, Goettlich-Riemann W (1972) Purification and properties of sheep plasma amine oxidase. Enzymologia 43(1): 33-44.
  • Stolen CM, Yegutkin GG, Kurkijarvi R, Bono P, Alitalo K, Jalkanen S. (2004) Origins of serum semicarbazide-sensi­tive amine oxidase. Circ Res 95: 50-57.
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  • Tipton KF, Boyce S, O’Sullivan J, Davey GP, Healy J (2004) Monoamine oxidases: certainties and uncertainties. Curr Med Chem 11: 1965-1982.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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