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2006 | 62 | 10 |

Tytuł artykułu

Distribution and morphology of the NOS-immunoreactive neurons in the thoracolumbar and sacral spinal cord of the pig

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The study investigated the distribution and morphology of nitric oxide synthesis-immunoreactive neuronal cell bodies and processes in the thoracolumbar and sacral spinal cord of sexually immature gilts. Investigations revealed the following: NOS-immunoreactive fibers and singular cell bodies in regions of the dorsal horn including superficial laminae I and II and deeper laminae III and IV; prominent NOS-immunolabeled perikarya in intermediolateral nucleus of the thoracolumbar spinal segments; NOS-positive perikarya in lamina X along the thoracic, lumbar and sacral divisions of the cord; NOS-positive perikarya and fibers in the area near to the location of the intermediomedial and intermediolateral nuclei in the sacral segments of the cord. The obtained morphological results indicate that the general distribution pattern of NOS-positive neurons in the spinal cord of pigs resembles that of other species. The concentration of NO-ergic neurons in the autonomic nuclei, dorsal horn laminae I, II, III, IV and lamina X suggests a prominent role of NO-ergic neurons in visceral and sensory functions.

Wydawca

-

Rocznik

Tom

62

Numer

10

Opis fizyczny

p.1134-1138,fig.,ref.

Twórcy

autor
  • University of Warmia and Mazury, Oczapowskiego 13, 10-719 Olsztyn, Poland
autor
autor
autor

Bibliografia

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  • 2.Bredt D. S., Snyder S. H.: Nitric oxide, a novel neuronal messenger. Neuron 1992, 8, 3-11.
  • 3.Bredt D. S., Snyder S. H.: Isolation of nitric oxide synthase, a calmodulin-requiring enzyme. Proc. Natl Acad. Sci. USA 1990, 87, 682-685.
  • 4.Całka J.: Role of nitric oxide in the hypothalamic control of LHRH and oxytocin release, sexual behavior and aging of the LHRH and oxytocin neurons. Fol. Histochem. Cytobiol. 2006, 44, 3-12.
  • 5.Doone G. V., Pelissier N., Manchester T., Vizzard M. A.: Distribution of NADPH-d and nNOS-IR in the thoracolumbar and sacrococcygeal spinal cord of the guinea pig. J. Auton. Nerv. Syst. 1999, 77, 98-113.
  • 6.Dun N. J., Dun S. L., Wu S. Y., Forstermann U., Schmidt H. H. H., Tseng L. F.: Nitric oxide synthase immunoreactivity in the rat, mouse, cat and squirrel monkey spinal cord. Neuroscience 1993, 54, 845-857.
  • 7.Dun N. J., Dun S. L., Forstermann U., Tseng L. F.: Nitric oxide synthase immunoreactivity in rat spinal cord. Neurosci. Lett. 1992, 147, 217-220.
  • 8.Foster J. A., Phelps P. E.: Neurons expressing NADPH-diaphorase in the developing human spinal cord. J. Comp. Neurol. 2000, 427, 417-427.
  • 9.Garthwaite J., Boulton C. L.: Nitric oxide signaling in the central nervous system. Annu. Rev. Physiol. 1995, 57, 683-706.
  • 10.Hancock M. B., Peveto C. A.: A preganglionic autonomic nucleus in the dorsal gray commissure of the lumbar spinal cord of the rat. J. Comp. Neurol. 1979, 183, 65-72.
  • 11.Henry J. L., Caleresu F. R.: Topography and numerical distribution of neurons of the thoracic-lumbar intermediolateral nucleus of the cat. J. Comp. Neurol. 1972, 144, 205-214.
  • 12.Kaleczyc J., W¹sowicz K., Klimczuk M., Czaja K., £akomy M.: Immunohistochemical characterisation of cholinergic neurons in the anterior pelvic ganglion of the male pig. Fol. Histochem. Cytobiol. 2003, 41, 65-72.
  • 13.Kluchova D., Schmidtova K., Rybarova S., Lovasova K., Pomfy M., Prosbova T., Vatl’ak A.: Partial colocalization of NADPH-diaphorase and acetylcholinesterase positivity in spinal cord neurons. Physiol. Res. 2000, 49, 151- -155.
  • 14.Luo Z. D., Cizkova D.: The role of nitric oxide in nociception. Curr. Rev. Pain. 2000, 4, 459-466.
  • 15.Marsala J., Lukacova N., Sulla I., Wohlfahrt P., Marsala M.: The evidence for nitric oxide synthase immunopositivity in the monosynaptic Ia-motoneuron pathway of the dog. Exp. Neurol. 2005, 195, 161-178.
  • 16.Swindle M. M., Moody D. C., Philips L. D.: Swine as models in biomedical research. Iowa State Univ. Press. Ames. 1992, 1-312.
  • 17.Tracey W. R., Nakane M., Pollock J. S., Förstermann U.: Nitric oxide synthase in neuronal cells, macrophages and endothelium are NADPH diaphoreses, but represent only a fraction of total cellular NADPH diaphorase activity. Biochem. Biophys. Res. Commun. 1993, 195, 1035-1040.
  • 18.Valtschanoff J. G., Weinberg R. J., Rustioni A.: NADPH diaphorase in the spinal cord of rats. J. Comp. Neurol. 1992, 321, 209-222.
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  • 20.Vizzard M. A., Erickson V. L., De Groat W. C.: Localization of NADPH diaphorase in the thoracolumbar and sacrococcygeal spinal cord of the dog. J. Auton. Nerv. Syst. 1997, 64, 128-142.

Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

bwmeta1.element.agro-article-831d9c5f-a6d2-4993-b4e9-cf5f52a72742
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