Hormony steroidowe - charakterystyka, zastosowanie, pozostalosci w zywnosci pochodzenia zwierzecego

• Autorzy: Wozniak B

Warianty tytułu

EN

Steroid hormones - properties, application, residues in food of animal origin

• Języki publikacji: PL

Abstrakty

EN

Hormones play an important role in the bodies of mammals because they act on metabolism and reproduction, as well as coordinate and regulate activities of different parts of the body, organs and tissues. Steroid hormones possess the capacity to increase weight gain and to reduce the feed conversion ratio, therefore they can be used for anabolic purposes in animal fattening. Taking into account the toxicity of hormones, particularly their cancerogenic and mutagenic properties, the use of this group of compounds for animal fattening purposes has been prohibited in the European Union, but natural hormones are allowed in some countries, for example USA and Australia. However, steroid hormones are also natural constituents of muscle and fatty tissues as well as of livers and kidneys of nontreated animals. Their occurrence is not restricted to mammals. Steroid hormones have also been determined in fish and poultry; they have been found in other animal-derived food such as milk and eggs. The residues of anabolic hormones in animal tissue as a result of implantation or illegal use can be a hazard for humans. Therefore the monitoring of hormone residues in biological samples of animal origin is mandatory. Several cases exceeding the acceptable limits of 17β-estradiol and testosterone in bovine serum were noted in Poland in the last five years. Moreover, the presence of endogenous 19-nortestosterone in the urine of pigs was observed and no residues of synthetic hormones in tissues of slaughter animals were found.

Słowa kluczowe

PL

hormony sterydowe; wlasciwosci; funkcje fizjologiczne; mechanizm dzialania; zastosowanie; toksycznosc; zywnosc pochodzenia zwierzecego; mieso; mleko; jaja; pozostalosci hormonow

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2010
• Tom: 66
• Numer: 03
• Opis fizyczny: s.177-181,rys.,bibliogr.

Twórcy

autor

Wozniak B

• Panstwowy Instytut Weterynaryjny - Panstwowy Instytut Badawczy, Al.Partyzantow 57, 24-100 Pulawy

Bibliografia

• 1.Aksglaede L., Juul A., Leffers H., Skakkebaek N. E., Andersson A. M.: The sensitivity of the child to sex steroids: possible impact of exogenous estrogens. Hum. Reprod. Update 2006, 12, 341-349.
• 2.Anon.: Chemical Review and International Harmonisation Section Office of Chemical Safety Therapeutic Goods Administration, Department of Health and Ageing: A review to update Australia's position on the human safety of residues of hormone growth promotants (HGPs) used in cattle. Canberra July 2003.
• 3.Anon.: European Commission Health & Consumer Protection Directorate-General. Opinion of the Scientific Committee on Veterinary Measures Relating to Public Health on Review of previous SCVPH opinions of 30 April 1999 and 3 May 2000 on the potential risks to human health from hormone residues in bovine meat and meat products. Brussels 10 April 2002.
• 4.Anon.: Evaluation of certain veterinary drug residues in food (Fifty-second report of the Joint FAO/WHO Expert Committee on Food Additives). WHO Technical Report Series, No. 893, Rome 2000.
• 5.Baulieu E. E., Kelly P. A.: Hormones. From molecules to disease. Hermann, Paris 1990.
• 6.Bayliss W. M., Starling E. H.: The mechanism of pancreatic secretion. J. Physiol. 1902, 28, 325-353.
• 7.Bouffault J. C.,Willemart J. P.: Anabolic activity of trenbolone acetale alone or in association with estrogens, [w:] Meissonnier E.: Anabolic in animal production. OIE, Paris 1983, 155-177.
• 8.Council Directive 88/146/EEC, Off. J. Eur. Commun. 1988, L 128:36.
• 9.Council Directive 96/22/EC, Off. J. Eur. Commun. 1996, L 125:3.
• 10.Courant F., Antignac J. P., Maume D., Monteau F., Andersson A. M., Skakkebaek N., André F., Le Bizec B.: Exposure assessment of prepubertal children to steroid endocrine disrupters. Analytical strategy for estrogens measurements in plasma at ultra-trace level. Anal. Chim. Acta 2007, 586, 105-114.
• 11.Doyle E.: Human safety of hormone implants used to promote growth in cattle. A review of the scientific literature. FRI Briefings. Food Research Institute, University of Wisconsin Madison, WI 53706, July 2000.
• 12.Fritsche S., Steinhart H.: Differences in natural steroid hormone patterns of beef from bulls and steers. J. Anim. Sci. 1998, 76, 1621-1625.
• 13.Fritsche S., Steinhart H.: Occurrence of hormonally active compounds in food: a review. Eur. Food Res. Technol. 1999, 209, 153-179.
• 14.Gerken C. L.,Tatum J. D., Morgan J. B., Smith G. C.: Use of genetically identical (Clone) steers to determine the effects of estrogenic and androgenic implants on beef quality and palatability characteristics. J. Anim. Sci. 1995, 73, 3317-3324.
• 15.Hartmann S., Lacorn M., Steinhart H.: Natural occurrence of steroid hormones in food. Food Chem. 1998, 62, 7-20.
• 16.IARC Monographs on the evaluation of carcinogenic risk of chemicals to humans. Vol. 21. Sex hormones (II). International Agency for Research on Cancer, Lyon 1979.
• 17.IARC Monographs on the evaluation of carcinogenic risk of chemicals to humans. Vol. 72. Hormonal Contraception and Post-menopausal Hormonal Therapy. International Agency for Research on Cancer, Lyon 1999.
• 18.IARC Overall evaluation of carcinogenicity: an updating of IARC Monographs Volumes 1 to 42. Supplement N° 7. International Agency for Research on Cancer, Lyon 1987.
• 19.Ingerowski G. H., Scheutwinkel-Reich M., Stan H. J.: Mutagenicity studies on veterinary anabolic drugs with the Salmonella/microsome test. Mutat. Res. 1981, 91, 93-98.
• 20.Johnson B. J., Anderson P. T., Meiske J. C., Dayton W. R.: Effect of a combined trenbolone acetate and estradiol implant on feedlot performance, carcass characteristics, and carcass composition of feedlot steers. J. Anim. Sci. 1996, 74, 363-371.
• 21.Kossila V. L.: The use of anabolic steroids in animal production, [w:] Meissonnier E.: Anabolic in Animal Production. OIE, Paris 1983, 497-503.
• 22.Liehr J. G.: Is estradiol a genotoxic mutagenic carcinogen? Endocrine Rev. 2000, 21, 40-54.
• 23.Lough D. S., Kahl S., Solomon M. B., Rumsey T. S.: The effect of trenbolone acetate on performance, plasma lipids, and carcass characteristic of growing ram and ewe lambs. J. Anim. Sci. 1993, 71, 2659-2665.
• 24.Lutz W. K., Deuber R., Caviezel M., Sagelsdorff P., Friederich U., Schlatter C.: Trenbolone growth promotant: covalent DNA binding in rat liver and in Salmonella typhimurium, and mutagenicity in the Ames test. Arch. Toxicol. 1988, 62, 103-109.
• 25.Martinez M., Lopezbote C., Sancho G., Ventanas J.: Effects of trenbolone acetate on swine carcass characteristics and backfat composition. Can. J. Anim. Sci. 1992, 72, 969-972.
• 26.Marzin D.: Ames test and trenbolone. Arch. Toxicol. 1989, 419, 33-41.
• 27.Metzler M., Kulling S. F., Pfeiffer E., Jacobs E.: Genotoxicity of estrogens. Z. Lebens. Unters. Forsch. 1998, 206, 367-373.
• 28.Meyer H. D., Karg H.: Growth stimulators for farm animals: mode of action, effects on meat quality and potential risk originating from residues. Proc. FAO/CAAS Workshop on Biotechnology in Animal Production and Health in Asia and Latin America, Beijing Oct. 9-13, 1989, s. 49-58.
• 29.Mutschler E., Geisslinger G., Kroemer H. K., Schäfer-Korting M.: Farmakologia i toksykologia. A. Danysz (red.), Wydawnictwo Medyczne Urban&Partner, Wrocław 2004.
• 30.Preston R. L.: Biological responses to estrogen additives in meat producing cattle and lambs. J. Anim. Sci. 1975, 41, 1414-1430.
• 31.Preston R. L.: Hormone containing growth promoting implants in farmed livestock. Adv. Drug Delivery Rev. 1999, 38, 123-128.
• 32.Regulation 178/2002/EC of the European Parliament and of the Council of 28 January 2002 laying down the general principles and requirements of food law, establishing the European Food Safety Authority and laying down procedures in matters of food safety. Off. J. Eur. Commun. 2002, L31/1.
• 33.Report of the Veterinary Products Committee. Risk Associated with the Use of Hormonal Substances in Food-Producing Animals. VPC, Woodham Lane, New Haw, Addlestone, Surrey, June 2006.
• 34.Richold M.: The genotoxicity of trenbolone, a synthetic steroid. Arch. Toxicol. 1988, 61, 249-258.
• 35.Rozporządzenie Ministra Rolnictwa i Rozwoju wsi z dnia 28 lipca 2006 roku w sprawie sposobu postępowania z substancjami niedozwolonymi, pozostałościami chemicznymi, biologicznymi, produktami leczniczymi i skażeniami promieniotwórczymi u zwierząt i w produktach pochodzenia zwierzęcego. Dz. U. Nr 147, poz. 1067.
• 36.Schänzer W.: Metabolism of anabolic androgenic steroids. Clin. Chem. 1996, 42, 1001-1020.
• 37.Stephany R. W., Sterk S. S., Van Ginkel L. A.: Tissue levels and dietary intake of endogenous steroids: an overview with emphasis on 17beta-estradiol. Proc. Euroresidue V Conference, Noordwijkerhout, The Nederlands 10-12 May 2004, s. 111-121.