Uncoupling proteins in mitochondria of plants and some microorganisms

• Autorzy: Jarmuszkiewicz W.
• Języki publikacji: EN

Abstrakty

EN

Uncoupling proteins, members of the mitochondrial carrier family, are present in mito­chondrial inner membrane and mediate free fatty acid-activated, purine-nucleo- tide-inhibited H+ re-uptake. Since 1995, it has been shown that the uncoupling protein is present in many higher plants and some microorganisms like non-photosynthetic amoeboid protozoon, Acanthamoeba castellanii and non-fermentative yeast Candida parapsilosis. In mitochondria of these organisms, uncoupling protein activity is revealed not only by stimulation of state 4 respiration by free fatty acids accompanied by decrease in membrane potential (these effects being partially released by ATP and GTP) but mainly by lowering ADP/O ratio during state 3 respiration. Plant and microorganism uncoupling proteins are able to divert very efficiently energy from oxidative phosphorylation, compet­ing for ΔμH+ with ATP synthase. Functional connection and physiological role of uncou­pling protein and alternative oxidase, two main energy-dissipating systems in plant-type mitochondria, are discussed.

Słowa kluczowe

EN

mitochondrion; protein; Acanthamoeba castellanii; uncoupling protein; fatty acid; alternative oxidase; Candida parapsilosis; plant

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2001
• Tom: 48
• Numer: 1
• Opis fizyczny: p.145-155,fig.

Twórcy

autor

Jarmuszkiewicz W.

• Adam Mickiewicz University, A.Fredry 10, 61-701 Poznan, Poland

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