Application of multiplex FISH, CGH and MSSCP techniques for cytogenetic and molecular analysis of transitional cell carcinoma [TCC] cells in voided urine specimens

• Autorzy: Constantinou M , Binka-Kowalska A , Borkowska E , Zajac E , Jalmuzna P , Matych J , Nawrocka A , Kaluzewski B
• Języki publikacji: EN

Abstrakty

EN

Multiplex FISH (UroVysion), Comparative Genomic Hybridization (CGH), and Multitemperature Single-Strand Conformation Polymorphism (MSSCP) were applied for non-invasive diagnosis and prognosis of bladder cancer. The UroVysion test was positive in 80% of patients with pTl and in 100% of patients with either pT2 or pT3 tumours. Tumours with pT3T4 stages were characterized by high numbers of chromosomal imbalances, detected by CGH. The mutation of the p53 gene was detected in 16% of patients, but only in those with pT2 or pT3 tumours.

Słowa kluczowe

EN

transitional cell carcinoma; Poland; cytogenetic analysis; molecular analysis; comparative genomic hybridization; gene mutation; multitemperature single-strand conformation polymorphism; bladder cancer; patient; UroVysion test; carcinoma; diagnosis; prognosis; mutation; tumour; p53 gene

• Wydawca: -
• Czasopismo: Journal of Applied Genetics
• Rocznik: 2006
• Tom: 47
• Numer: 3
• Opis fizyczny: p.272-275,fig.,ref.

Twórcy

autor

Constantinou M

• Department of Medical Genetics, Medical University of Lodz, Sterlinga 1/3, 91-425 Lodz, Poland

autor

Binka-Kowalska A

• Department of Medical Genetics, Medical University of Lodz, Sterlinga 1/3, 91-425 Lodz, Poland

autor

Borkowska E

• Department of Medical Genetics, Medical University of Lodz, Sterlinga 1/3, 91-425 Lodz, Poland

autor

Zajac E

• Department of Medical Genetics, Medical University of Lodz, Sterlinga 1/3, 91-425 Lodz, Poland

autor

Jalmuzna P

• Department of Urology and Transplantology of Kidneys, The Dr. M. Pirogow Specjalist Hospital in Łódź, Poland

autor

Matych J

• Department of Urology and Transplantology of Kidneys, The Dr. M. Pirogow Specjalist Hospital in Łódź, Poland

autor

Nawrocka A

• Chair and Department of Pathomorphology, Medical University of Łódź, Poland

autor

Kaluzewski B

• Department of Urology and Transplantology of Kidneys, The Dr. M. Pirogow Specjalist Hospital in Łódź, Poland

Bibliografia

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