A new SNP in the promoter region of the porcine MYF5 gene has no effect on its transcript level in m.longissimus dorsi

• Autorzy: Urbanski P , Flisikowski K , Starzynski R R , Kuryl J , Kamyczek M
• Języki publikacji: EN

Abstrakty

EN

Myogenic factor 5 (myf-5) is the product of the MYF5 gene, belonging to the MyoD family. This transcription factor participates in the control of myogenesis. We identified 3 new mutations in the promoter region of the gene: A65C, C580T and C613T. The aim of this study was to evaluate the influence of the A65C transversion on gene expression. The analysis was conducted on 15 Polish Large White gilts. The relative content of MYF5 mRNA in m. longissimus dorsi did not differ significantly across MYF5 genotypes (AA, AC, CC). This result suggests that the A65C transversion may not play an important role in the expression of the MYF5 gene in analysed adult muscle but it abolishes a putative binding site for two transcription factors (CDP and HSF1) and creates such a site for Sp1.

Słowa kluczowe

EN

pig; MYF5 gene; MyoD family; transcription factor; porcine gene; promoter region; gene expression; new mutation; polymerase chain reaction

• Wydawca: -
• Czasopismo: Journal of Applied Genetics
• Rocznik: 2006
• Tom: 47
• Numer: 1
• Opis fizyczny: p.59-61,ref.

Twórcy

autor

Urbanski P

• Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, Postepu 1, 05-552 Wolka Kosowska, Poland

autor

Flisikowski K

• Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, Postepu 1, 05-552 Wolka Kosowska, Poland

autor

Starzynski R R

• Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, Postepu 1, 05-552 Wolka Kosowska, Poland

autor

Kuryl J

• Institute of Genetics and Animal Breeding, Polish Academy of Sciences, Jastrzebiec, Postepu 1, 05-552 Wolka Kosowska, Poland

autor

Kamyczek M

• National Research Institute of Animal Production, Experimental Station, Pawłowice, Poland

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