Wplyw diet o roznej zawartosci bialka na wybrane parametry metabolizmu wapniowo-fosforanowego u szczurow narazonych na dzialanie pestycydow. Cz.I. Tiuram

• Autorzy: Witkowska D.
• Języki publikacji: PL

Abstrakty

PL

Badano wpływ wielokrotnego narażenia na tiuram (4 tygodnie) w dawce 5% LD50, na transport wapnia i fosforu w jelicie oraz stężenie tych pierwiastków w surowicy i kości udowej szczurów karmionych dietami o różnej zawartości białka (7,5%, 10,3%, 22,7% - dieta standardowa i 30,6%).

EN

Effects of 5% LD50 thiram on selected parameters of calcium and phosphorus metabolism (transport of both elements in the gut and their concentration in blood serum and femur) were investigated in Wistar rats maintained on diets containing different levels of protein. The content of protein in diets was 7.5%, 10.3%, 22.7% and 30.6%. Thiram was administered as a soybean oil suspension by a stomach tube at 29 mg/kg body wt., six times a week for 7,14 or 28 days. The control animals received an equal amount of soybean oil. The intestinal transport of calcium and phosphorus was estimated using the everted sacs method. The levels of calcium in blood serum and femur were determined by AAS, whereas phosphorus was determined by colorimetry. It has been shown that repeated exposure to thiram of rats maintained on diets containing different levels of protein caused inhibition of calcium and phosphorus transport in the gut in the manner dependent on the time of intoxication and protein content in the diet. In rats maintaind on protein-deficient (7.5% and 10.3% protein) diets, calcium transport inhibition occurred earlier (after 1 and 2 weeks of intoxication, respectively) and was more pronounced than in rats receiving standart or protein-rich diet. Phosphorus transport was inhibited in all experimental groups, but the highest changes were observed in the group receiving the diet containing 7.5% protein.

Słowa kluczowe

PL

szczury; zwierzeta laboratoryjne; bialko; wapn; dieta; tiuram; pestycydy; fosfor; metabolizm wapniowo-fosforanowy; zawartosc bialka; toksycznosc

EN

rat; laboratory animal; protein; calcium; diet; thiram; pesticide; phosphorus; calcium metabolism; phosphate metabolism; protein content; toxicity

• Wydawca: -
• Czasopismo: Bromatologia i Chemia Toksykologiczna
• Rocznik: 1996
• Tom: 29
• Numer: 4
• Opis fizyczny: s.343-352,tab.,wykr.,rys.,bibliogr.

Twórcy

autor

Witkowska D.

• Akademia medyczna, 02-097 Warszawa, ul.Banacha 1

Bibliografia

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