Farmakokinetyka tramadolu oraz jego glownych metabolitow po jednorazowym podaniu per os tabletki o przedluzonym uwalnianiu oraz czopkow per rectum u psow

• Autorzy: Lebkowska-Wieruszewska B , Kowalski C.J. , Saccomanni G. , Giorgi M.

Warianty tytułu

EN

Pharmacokinetics of tramadol and its major conjugates after a single per os administration of a sustained tablet and per rectum suppositories formulations in dogs

• Języki publikacji: PL

Abstrakty

EN

The aim of the present study is to evaluate the pharmacokinetics of T and its major metabolites M1, M2 and M5 after the single oral administration of an SR tablet and rectal suppositories in dogs (4-6 mg·kg⁻¹ m.c.). The plasma concentration data after SR-tablet and rectal administration were fitted on the basis of a mono- and non-compartmental model, respectively. T plasma concentration after SR tablet administration was quantitatively detected in three dogs, M1 was quantized in only one dog while M2 and M5 were quantized in all the dogs. T showed median values of Cmax, Tmax and T₁/₂ of 40 (20-170) ng·mL⁻¹, 3 (4-2) and 1.88 (2.21-1.44) hours, respectively. M5 showed median values of Cmax, Tmax and T₁/₂ of 0.1 (90-190) ng·mL⁻¹, 2 (3-1) and 4.23 (6.58-1.85) hours, respectively. M2 showed median values of Cmax, Tmax and T₁/₂ of 220 (80-330) ng·mL⁻¹, 4 (7-3) and 4.49 (6.39-1.57) hours, respectively. Following rectal administration, T was detected from 5 minutes up to 10 h in a smaller amount than M5 and M2. T median value of Cmax was 140 ± 60 ng·mL⁻¹ in 0.56 ± 0.41 h (Tmax). K₀₁ t₁/₂ and K₁₀ t₁/₂ were 0.27 ± 0.25 h and 2.24 ± 1.82 h, respectively. M1 was detectable from 5 min up to 2 h, showing low values (7-28 ng·mL⁻¹). The present findings suggest oral SR tablet and suppository rectal formulation have similar pharmacokinetic behavior and would not have suitable pharmacokinetic characteristics to be administered once-a-day as an effective and safe treatment for pain in dogs.

Słowa kluczowe

PL

psy; leki przeciwbolowe; tramadol; podawanie doustne; tabletki o przedluzonym uwalnianiu; podawanie doodbytnicze; czopki; metabolity; farmakokinetyka; parametry farmakokinetyczne

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2009
• Tom: 65
• Numer: 10
• Opis fizyczny: s.687-692,rys.,tab.,bibliogr.

Twórcy

autor

Lebkowska-Wieruszewska B

• Uniwersytet Przyrodniczy w Lublinie, ul.Akademicka 12, 20-033 Lublin

autor

Kowalski C.J.

autor

Saccomanni G.

autor

Giorgi M.

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