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2006 | 62 | 07 |

Tytuł artykułu

Zastosowanie modelu Stewarta do analizy zaburzen rownowagi kwasowo-zasadowej u psow z przewlekla niewydolnoscia nerek

Warianty tytułu

EN
Applications of the Stewart model for the analysis of acid-base disturbances in dogs with chronic renal insufficiency

Języki publikacji

PL

Abstrakty

EN
The objective of these studies was to introduce the Stewart approach to analyses of acid-base changes in dogs with the chronic renal failure (CRF). The acid-base status was investigated in 12 healthy dogs and 20 dogs with CRF. In the CRF affected dogs the level of urea and creatinin rose to 350 mg/dl and 394.8 µmol/l respectively. The three independence variables (Pсо₂, SID-strog ion difference, and the Atot-sum of net charges of nonvolatile plasma buffers (albumin + inorganic phosphate) together with the strong ion gap (SIG) were calculated by a method adopted from articles employing Stewart’s approach. The SID averaged 41.85 mEq/l and 48.81 mEq/l in normal and diseased dogs respectively. Nonvolatile plasma buffers (Atot) were higher especially in more severely diseased dogs. The most considerable changes in affected dogs have been observed in SIG where, together with the increasing values of urea, the quantity of SIG successively dropped, attaining negative values (-28.03 mEq/l). The albumin values were significantly associated with the SID values. All affected dogs have metabolic acidosis partly compensated by respiratory alkalosis. As has been clearly observed the estimation of SIG may be used as an accurate marker of CRF in dogs.

Wydawca

-

Rocznik

Tom

62

Numer

07

Opis fizyczny

s.837-839,rys.,tab.,bibliogr.

Twórcy

autor
  • Akademia Rolnicza, ul.Gleboka 30, 20-612 Lublin
autor
autor
autor

Bibliografia

  • 1. Alfaro V., Pesquero J., Palacios L.: Acid-base disturbance during hemorrhage in rats: significant role of strong inorganic ions. J. Appl. Physiol. 1999, 86, 1617-1625.
  • 2. Bobowiec R., Wójcik M., Martelli F., Tusińska E.: Zmiany luki anionowej indukowane NH₄Cl i furosemidem u królików. Medycyna Wet. 2002, 58, 456-461.
  • 3. Constable P. D.: Total weak acid concentration and effective dissociation constant of nonvolatile buffers in human plasma. J. Appl. Physiol. 2001, 91, 1364-1371.
  • 4. Constable P. D., Hinchcliff K. W., Muir W. W.: Comparison of anion gap and strong ion gap as predictors of unmeasured strong ion concentration in plasma and serum from horses. Am. J. Vet. Res. 1998, 59, 881-887.
  • 5. Constable P. D.: A simplified strong ion model for acid-base equilibria: application to horse plasma. J. Appl. Physiol. 1997, 83, 297-311.
  • 6. Corney H. E.: Stewart and beyond: New models of acid-base balance. Kidney Int. 2003, 64, 777-787.
  • 7. Darcy H.: Relationship between urine ammonium ion excretion and urine anion gap in dogs: Am. J. Res. 1991, 52, 1956-1959.
  • 8. Figge J., Mydosh T., Fencl V.: Serum proteins and acid-base equilibria: a follow-up. J. Lab. Clin. Med. 1992, 120, 713-719.
  • 9. Fencl V., Leith D. E.: Stewart,s quantitative acid-base chemistry: Applications in biology and medicine. Respiration Physiol. 1993, 91, 1-16.
  • 10. Gluck S. L.: Acid-base. Lancet 1998, 352, 474-479.
  • 11. Kellum J. A.: Recent advances in acid-base physiology applied to critical care. Intensivmed 2000, 37, 541-548.
  • 12. Parker A. J., Hamlin G. P., Coleman C. J., Fitzpatrick L. A.: Quantitative analysis of acid base in Bos indicus steers subjected to transportation of long duration. J. Anim. Sci. 2003, 81, 1434-1439.
  • 13. Szenci O., Felkai F., Märcz I., Takács E.: Ionized calcium, total calcium and acid-base values of blood in healthy and acidotic dogs. J. Vet. Med. A 1998, 35, 125-128.
  • 14. Whitehair K. J., Haskins S. C., Whitehair J. G., Pascoe P. J.: Clinical applications of quantitative acid-base chemistry. J. Vet. Intern. Med. 1995, 9, 1-11.

Typ dokumentu

Bibliografia

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Identyfikator YADDA

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