The effect of phytoestrogens on the reproductive tract

• Autorzy: Slomczynska M.
• Języki publikacji: EN

Abstrakty

EN

Environmental estrogens may be derived from plants (phytoestrogens), pharmaceuticals or synthetic compounds. They exert estrogenic and/or potentially antiestrogenic effects on farm animals, wildlife and humans. Exposure to these compounds results in some abnormalities in the reproductive tract, changes in the estrous cycle, and possibly protection against the development of hormone- dependent cancer. The data obtained from animal studies suggest that the timing of exposure to phytoestrogens is important, and neonatal exposure causes the most pronounced effects.

Słowa kluczowe

EN

man; fertility; animal; phytoestrogen; reproductive tract; breast cancer

• Wydawca: -
• Czasopismo: Polish Journal of Veterinary Sciences
• Rocznik: 2004
• Tom: 07
• Numer: 3
• Opis fizyczny: p.223-226,ref.

Twórcy

autor

Slomczynska M.

• Jagiellonian University, Ingardena 6, 30-060 Krakow, Poland

Bibliografia

• Adams NR (1995) Detection of the effects of phytoestro­gens on sheep and cattle. J Anim Sci 73: 1509-1515. Burton JL, Wells M (2002) The effect of phytoestrogens on the female genital tract J Clin Pathol 55: 401-407.
• Brown NM, Setchell KDR (2001) Animal models impacted by phytoestrogens in commercial chow: implications for pathways influenced by hormones Lab Investig 81: 735-747.
• Burroughs CD, Mills KT, Bern HA (1990) Reproductive abnormalities in female mice exposed neonatally to vari­ous doses of coumestrol. J Toxicol Environ Health 30: 105-122.
• Clarke R, Hilakivi-Clarke L, Trock B (2001) Breast cancer: dietary and environmental oestrogens. Biologist 48: 21-26.
• Desbrow C, Routledge EJ, Brighty GC (1998) Identification of estrogenic chemicals in STW effluent 1. Chemical frac­tion and in vitro biological screening. Environ Sci Tech- nol 11: 1549-1558.
• Duncan AM, Merz BE, Xu X (1999) Soy isoflavones exert modest hormonal effects in premenopausal women. J Clin Endocrinol Metab 84: 192-197.
• Erdman JW (1995) Control of serum lipids with soy protein. New England J Med 333: 313-315.
• Goodman MT, Wilkens LR, Hankin JH (1997) Association of soy and fiber consumption with the risk of endometrial cancer Am J Epidemiol 146: 294-306.
• Humfrey CD (1998) Phtyoestrogens and human health ef­fects: weighing up the current evidence. Nat Toxins 6: 51-59.
• Juniewicz PE, Pallante MS, Moser A, Ewing LL (1988) Identification of phytoestrogens in the urine of male dogs. J Steroid Biochem 6: 987-994.
• Kuiper GG, Enmark E, Pelto-Huikko M, Nilsson S, Gustaf­sson JA (1996) Cloning of a novel receptor expressed in rat prostate and ovary. Proc Natl Acad Sci USA 93: 5925-5930.
• Morito K, Aomori T, Hirose T, Kinjo J, Hasegawa J, Ogawa S, Inoue S, Muramatsu M, Masamune Y (2002) Interac­tion of phytoestrogens with estrogen receptors a and (5 (II) Biol Pharm Bull 25: 48-52.
• Picherit C, Dalle G, Neliat G, Lebecque P, Davicco MJ, Barlet JP, Coxam V (2000) Genistein and daidzein modulate in vitro rat uterine contractile activity. J Steroid Biochem Mol Biol 75: 201-208.
• Setchell KD, Gosselin SJ, Welsh MB, Johnston JO, Balistreri WF, Dresser BL, Tarr MJ (1987) Dietary estrogens- a probable cause of infertility and liver disease in captive cheetahs. Gastroenterology 93: 225-233.
• Setchell KD, Cassidy A (1999) Dietary isoflavones: Biologi­cal effects and relevance to human health. J Nutr 129: 758S-767S.
• Sharpe RM, Skakkebaek NE (1993) Are estrogens involved in falling sperm counts and disorders of the male tep- roduction tract? Lancet 341: 1392-1395.
• Wuttke W, Jarry H, Becker T, Schultens A, Christoffel V, Gorkow C, Seidlova- Wuttke D (2003) Phytoestrogens: endocrine disruptures or replacement for hormone re­placement therapy? Maturitas 44 Suppl 1: S9-20.