Activity of platelet alpha-6-fucosyltransferase is inversely related to blood platelet concentration

• Autorzy: Koscielak J. , Antoniewicz-Papis J. , Zdebska E. , Maj S. , Leszko B.
• Języki publikacji: EN

Abstrakty

EN

The activity of serum a-6-fucosyl transferase, a platelet derived enzyme, determined in sera of 22 normal individuals and 86 patients with various disorders was positively correlated with platelet counts. When the enzyme activity in 1 jil serum was calculated per 1000 of platelets in blood (coefficient F/P) an inverse correlation became evident in that F/P was proportionally the higher the lower was platelet count in blood. The F/P values were in a good agreement with the results of direct assays of enzyme activities in isolated platelets. Neither granulocytes, lymphocytes nor red cells signi­ficantly contributed to serum enzyme activity though granulocytes enhanced the thrombin-induced enzyme release from platelets. In platelets separated by centri- fugation in density gradients the enzyme was shown to be present in platelets of intermediate and high density but missing from the light ones. It is suggested that a-6-fucosyltransferase of platelets may be a marker of the ploidy level of mega­karyocytes.

Słowa kluczowe

EN

alpha-6-fucosyltransferase; blood enzyme; platelet concentration; platelet

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1995
• Tom: 42
• Numer: 1
• Opis fizyczny: p.35-39,fig.

Twórcy

autor

Koscielak J.

• Institute of Hematology and Blood Transfusion, Chocimska 5, 00-957 Warsaw, Poland

autor

Antoniewicz-Papis J.

autor

Zdebska E.

autor

Maj S.

autor

Leszko B.

Bibliografia

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