Time-dependent modification of model membrane properties by benzylammonium chlorides

• Autorzy: Gabrielska J. , Sarapuk J. , Kleszczynska H. , Przestalski S.
• Języki publikacji: EN

Abstrakty

EN

The nature of the interaction between some strong antifungal compounds and model membranes was studied. It was found that these compounds (N-dodecyl-N,N-dimethyl-N-/3- (β-methyl-β-nitrovinyl 1-6-methoxybenzyl/ammonium chloride and its derivatives) significantly change the properties of liposomes, planar lipid bilayers (BLM) and erythrocytes. The changes observed (i.e., release of praseodymium ions from liposomes and gradually diminished stability of BLM) in the presence of the compounds studied, as well as hemolysis of red blood cells, were time-dependent. It was also found that they depended on the polar head structure of the compounds.

Słowa kluczowe

EN

liposome; biological activity; erythrocyte; benzylammonium chloride; membrane stability; antifungal compound

• Wydawca: -
• Czasopismo: Polish Journal of Environmental Studies
• Rocznik: 1993
• Tom: 02
• Numer: 3
• Opis fizyczny: p.15-19,fig.,ref.

Twórcy

autor

Gabrielska J.

• Agricultural University, Norwida 25, 50-375 Wroclaw, Poland

autor

Sarapuk J.

autor

Kleszczynska H.

autor

Przestalski S.

Bibliografia

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