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2006 | 62 | 12 |

Tytuł artykułu

Effects of 2,4-dichlorophenoxyacetic acid [2,4-D] treatment on the epididymal spermatozoa, blood serum transaminases and its accumulation in liver of rats

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
Phenoxyacetic acid herbicides constitute one of the largest groups of herbicides used in the world. The study was carried out to investigate the effect of herbicide 2,4-D (2,4-Dichlorophenoxyacetic acid) on some blood parameters and toxicity of the male reproductive system of Sprague Dawley (CD) rats. The level of 2,4-D in the liver and its metabolite: 2,4-DCP was ascertained using the HPLC method and the organ weight of the livers was also determined. Three different concentrations of pesticide were used. The animals were treated orally 25 ppm and 50 ppm with water and 50 ppm and 100 ppm with food for 30 days. No significant difference was found in the blood parameters between the groups. The level of 2,4-D in the liver was found to be significantly higher in both feed and water groups compared to those of the control group (p<0.01). The level of 2,4-DCP in the liver also increased in all the experimental groups compared to control (p<0.01) groups, with the exception of the water group which had the lowest concentration. As far as the abnormal spermatozoa rates of rats were concerned, the values of the experimentally fed groups were higher than the control group and the difference between them was statistically significant (p<0.01).

Wydawca

-

Rocznik

Tom

62

Numer

12

Opis fizyczny

p.1378-1380,ref.

Twórcy

autor
  • Istanbul University, 34320 Avcilar, Istanbul, Turkey
autor
autor
autor

Bibliografia

  • 1.Ahlborg U. G., Thunberg T. M.: Chlorinated phenols: Occurrence, toxicity, metabolism and environmental impact. CRC Crit. Rev. Toxicol. 1980, 7, 1-35.
  • 2.Air Force Health Study (AFHS): An epidemiologic investigation of health effects in air force personel following exposure to herbicides-reproductive outcomes. Scand. J. Work. Environ. Health. 1992, 15, 227-233.
  • 3.Anon.: WHO. 2,4-dichlorophenoxyacetic acid (2,4-D)-Environmental aspects, [in:] Environmental Health Criteria, FAO/WHO, Geneva, Switzerland 1986, p. 92.
  • 4.Aydin H., Ozdemir N., Uzunoren N.: Investigation of the accumulation of 2,4-dichlorophenoxyacetic acid (2,4-D) in rat kidneys. Forensic Sci. Int. 2005, 153, 53-57.
  • 5.Balagué C. E., De Ruiz C. S., Rey R., Evangelista De Duffard A. M., Nader- -Macías M. E.: Effect of the herbicide 2,4-dichlorophenoxyacetic acid on uropathogenic Escherichia coli virulence factors. Toxicology 2002, 177, 143-155.
  • 6.Centers For Disease Control (CDC): Health status of Vietnam veterans III. Reproductive outcomes and child health. The centers for disease control Vietnam experience study. J. Am. Med. Assoc. 1988, 259, 2715-2719.
  • 7.Deregowski K, Sulik M., Kemona A., Stefanska-Sulik E.: Distribution and elimination of C-2,4-dichlorophenoxyacetic acid (2,4-D) in rat tissues in acute poisoning. Rocz. Panstw. Zakl. Hig. 1990, 41, 71-74.
  • 8.Duchnowicz P., Koter M., Duda W.: Damage of erythrocyte by phenoxyacetic herbicides and their metabolites. Pesticide Biochem. Phys. 2002, 74, 1-7.
  • 9.Ferri A., Duffard R., Sturtz N., Evangelista A. M.: Iron, zinc and copper levels in brain, serum and liver of neonates exposed to 2,4-dichlorophenoxyacetic acid. Neurotoxicol. Teratol. 2003, 25, 607-613.
  • 10.Keith L. H., Telliard W. A.: Priority pollutants: I. A prospective view, Environ. Sci. Technol. 1979, 13, 416-424.
  • 11.Khanna S., Fong S. C.: Metabolism of C-14 labeled 2,4-dichlorophenoxyacetic acid in rats. J. Agric. Food Chem. 1966, 14, 500.
  • 12.Koziollek P., Knackmuss H. J., Taeger K., Pagga U.: A dynamic river model for biodegradability studies. Biodegradation 1996, 7, 109-120.
  • 13.Lerda D., Rizzi R.: Study of reproductive function in persons occupationally exposed to 2,4-dichlorophenoxyacetic acid (2,4-D). Mutat. Res. 1991, 262, 47-50.
  • 14.Mikov I., Milosevic M., Mikov A., Mikov M.: Increased urinary excretion of thioethers as a marker for detecting exposure to herbicide containing 2,4-dichlorophenoxyacetic acid dimethylamine-experimental study on mice. Ann. Agric. Environ. Med. 2000, 7, 61-63.
  • 15.Oakes D. J., Webster W. S., Brown-Woodman P. D. C., Ritchie H. E.: Testicular changes induced by chronic exposure to the herbicide formulation, Tordon 75D® (2,4-dichlorophenoxyacetic acid and picloram) in rats. Rep. Toxicol. 2002, 16, 281-289.
  • 16.Paulino C. A., Guerra J. L., Oliveira G. H., Palermo-Neto J.: Acute, subchronic and chronic 2,4-dichlorophenoxyacetic acid (2,4-D) intoxication in rats. Vet. Hum. Toxicol. 1996, 38, 348-352.
  • 17.Sauerhoff M. W., Braun W. H., Blau G. E., Gehrýng P. J.: The fate of 2,4-dichlorophenoxyacetic acid (2,4-D) following oral administration to man. Toxicology 1977, 8, 3.
  • 18.Zhang J. F., Liu H., Sun Y. Y., Wang X. R., Wu J. C., Xue Y. Q.: Responses of the antioxidant defenses of the Goldfish Carassius auratus, exposed to 2,4-dichlorophenol. Environ. Toxicol. Pharmacol. 2005, 19, 185-190.

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Bibliografia

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