Small is beautiful: major modifications in DNA structure or dynamics by small substituents or ligands

• Autorzy: Guschlbauer W.
• Języki publikacji: EN

Abstrakty

EN

This short review assembles the contributions of the author's laboratory to the structural aspects of DNA. DNA was modified by small ligands and/or substituents. There are three aspects to this work: a) Protonation of guanosine and DNA and the formation of triple- and quadruple-strands of guanosine, its nucleotides, their polymers and DNA. b) Substitution of the 2'-position of deoxyribose by the most polar atom, fluorine: studies on 2'-deoxy-2'-fluoro-nucleosides, -nucleotides and their polymers, studied both by structural and biological methods. c) The effect of introducing the methyl group in the large groove of DNA: NMR studies of oligonucleotides containing N6-methylated adenine residues, and enzymatic and molecular biology work on Dam methylase are reported.

Słowa kluczowe

EN

DNA structure; substituent; DNA large groove; DNA methylation; fluorine; oligonucleotide; 2'-deoxy-2'-fluoro-nucleoside; protonated polynucleotide; ligand; N6-methylated adenine; guanosine; dynamics; modification

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1996
• Tom: 43
• Numer: 1
• Opis fizyczny: p.77-94,fig.

Twórcy

autor

Guschlbauer W.

• Service de Biochimie et Genetique Moleculaire, Bat.142, F-91191 Gif-sur-Yvette Cedex, France

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