The mystery of reactive oxygen species derived from cell respiration

• Autorzy: Nohl H. , Gille L. , Staniek K.
• Języki publikacji: EN

Abstrakty

EN

Mitochondrial respiration is considered to provide reactive oxygen species (ROS) as byproduct of regular electron transfer. Objections were raised since results ob­tained with isolated mitochondria are commonly transferred to activities of mito­chondria in the living cell. High electrogenic membrane potential was reported to trigger formation of mitochondrial ROS involving complex I and III. Suggested bioenergetic parameters, starting ROS formation, widely change with the isolation mode. ROS detection systems generally applied may be misleading due to possible interactions with membrane constituents or electron carriers. Avoiding these prob­lems no conditions reported to transform mitochondrial respiration to a radical source were confirmed. However, changing the physical membrane state affected the highly susceptible interaction of the ubiquinol/&C1 redox complex such that ROS for­mation became possible.

Słowa kluczowe

EN

superoxide; cell respiration; bc1 complex; mitochondrion; hydrogen peroxide; reactive oxygen species; phospholipid membrane

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2004
• Tom: 51
• Numer: 1
• Opis fizyczny: p.223-229,fig.,ref.

Twórcy

autor

Nohl H.

• University of Veterinary Medicine Vienna, Veterinarplatz 1, A-1210 Vienna, Austria

autor

Gille L.

autor

Staniek K.

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