NAD-analogues as potential anticancer agents: Conformational restrictions as basis for selectivity

• Autorzy: Pankiewicz K. W. , Zatorski A. , Watanabe K.A.
• Języki publikacji: EN

Abstrakty

EN

Cofactor type inhibitors (NAD-analogues) of IMP-dehydrogenase (IMPDH) were synthesized and their application as potential anticancer agents are discussed. C-nucleoside isosteres of NAD, C-NAD and C-PAD, showed an effective competitive inhibition of IMPDH. C-NAD but not C-PAD caused extremely potent inhibition of alcohol dehydrogenase. We also synthesized compounds in which nicotinamide riboside was replaced with tia/.ofurin (TAD-analogues) and the 2' and 3'-positions of adenosine part were fluorinated. The ribose ring of 2'-deoxy-2'-fluoroadenosine is in the Cy-endo conformation whereas 3-deoxy-3'-fluoroadenosine favors the Q2'-endo sugar pucker. These derivatives are good inhibitors of IMPDH type II, the isoenzyme dominant in neoplastic cells. In contrast, all these analogues showed rather week inhibitory activity against alcohol dehydrogenase. Nicotinamide riboside derivatives in which the base and the sugar are linked through an oxygen or a methylene bridge were synthesized. NAD-analogues containing such conformationally restricted nicotinamide nucleoside moiety (syn or anti) are expected to be selective inhibitors of B-specific (IMPDH) or A-specific dehydrogenases, respectively.

Słowa kluczowe

EN

inosine 5'-monophosphate; ribose; anticancer agent; alcohol dehydrogenase; tiazofurin; dehydrogenase; inhibitor

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1996
• Tom: 43
• Numer: 1
• Opis fizyczny: p.183-193

Twórcy

autor

Pankiewicz K. W.

• Oncor Pharm, 200 Perry Parkway, Gaithersburg, MD 20877, U.S.A.

autor

Zatorski A.

autor

Watanabe K.A.

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