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Czasopismo

2000 | 59 | 4 |

Tytuł artykułu

Substance-P of neural cells in human trigeminal ganglion

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
Expression of substance-P in human neurons of trigeminal ganglia has been investigated by immunohistochemistry and morphometry. These neurons constituted 12.8% to 32.6% of the total neuronal population in the trigeminal ganglia. Substance-P positive granulations were concentrated around the nucleus, distributed focally in neuroplasm or dispersed over the neuroplasm. Morphometric analysis has indicated the presence of three populations of SP-positive cells: small, medium-sized and large. The results suggest a functional differentiation on the level of the first neurons of the afferent path of the stomatognatic system. Substance-P is likely to play a role in the transmission not only of nociceptive impulses but also of those involved in the mechano-functional stimulation of system activities.

Wydawca

-

Czasopismo

Rocznik

Tom

59

Numer

4

Opis fizyczny

p.327-331,fig.

Twórcy

  • Medical University of Gdansk, Orzeszkowej 18, 80-208 Gdansk, Poland
autor

Bibliografia

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  • 2. Cuello AC, Galfre G, Milstein C (1979) Detection of substance-P in the central nervous system by a monoclonal antibody. Proc Natl Acad Sci USA, 76: 3532–3536.
  • 3. Del Fiacco M, Cuello AC (1990) Substance P- and enkephalin- containing neurons in the rat trigeminal system. Neuroscience, 5: 803–815.
  • 4. Del Fiacco M, Quartu M, Floris A, Diaz G (1990) Substance P-like immunoreactivity in human trigeminal ganglion. Neurosci Lett, 110: 16–21.
  • 5. Del Fiacco M, Diaz G, Floris A, Quartu M (1991) Substance P-containing and calcitonin gene related peptide-containing neurons in the human trigeminal ganglion. Immunohistochemical detection, morphometric characterization, and coexistence of peptides. Ann NY Acad Sci, 632: 382–384.
  • 6. Dubner G, Gobel K, Price D (1976) Peripheral and central trigeminal pain pathways. In: Binica JJ, Albe-Fessard D (eds) Advances in pain research and therapy, Raven Press, New York, 137–148.
  • 7. Fried K, Arvidsson J, Robertson B, Brodin E, Theodorsson E (1989) Combined retrograde tracing and enzyme/immunohistochemistry of trigeminal ganglion cell bodies innervating tooth pulps in the rat. Neuroscience, 33: 101–109.
  • 8. Fried K, Arvidsson J, Robertson B, Pfaller K (1991) Anterograde horseradish peroxidase tracing and immunohistochemistry of trigeminal ganglion tooth pulp neurons after dental nerve lesions in the rat. Neuroscience, 43: 269–278.
  • 9. Hökfelt T, Kellerth JO, Nilsson G, Pernow B (1975) Experimental/immunohistochemical studies on the localization and distribution of Substance-P in cat primary sensory neurons. Brain Res, 100: 235–252.
  • 10. Hökfelt T, Kellerth JO, Nilsson G, Pernow B (1975) Substance P localization in the central nervous system and in some primary sensory neurons. Science, 190: 889–890.
  • 11. Hökfelt T, Elde R, Johansson O, Lulft R, Nilsson G, Arimuda A (1976) If immunohistochemical evidence for separate populations of somatostatin-containing and substance-P-containing primary afferent neurons in the rat. Neuroscience, 1: 131–135.
  • 12. Hökfelt T, Skirboll L, Lundberg JM, Dalsgaard CJ, Johansson O, Pernow B, Janlcso G (1983) Neuropeptides and pain pathways. In: Bonica JJ, Lindbloffi U, and Iggo A (eds) Advances in pain research and therapy, 227–246.
  • 13. Kai-Kai M (1989) Cytochemistry of the trigeminal and dorsal root ganglia and spinal cord of the rat. Comp Biochem Physiol, 93: 189–193.
  • 14. Kuwayama Y, Stone R (1986) Neuropeptide immunoreactivity of pericellular baskets in the guinea pig trigeminal ganglion, Neurosci Lett, 64: 169–172.
  • 15. Leach JD, Cameron AA, Snow PJ (1985) Neuropeptides in physiologically identified mammalian sensory neurons. Neurosci Lett, 56: 257–263.
  • 16. Lehtosalo JI, Uusitalo H, Sijerrschartz J, Palkama A (1984) Substance P-like immunoreactivity in the trgieminal ganglion. A fluorescence light and electron microscope study. Histochem J, 80: 421–427.
  • 17. Lembeck F, Zetler G (1962) Substance P: A polypeptide of possible physiological significance, especially within the nervous system. Int Rev Neurobiol, 4: 159–215.
  • 18. Liungdahl A, Hökfelt T, Nilsson G (1978) Distribution of substance P-like immunoreactivity in the central nervous system of the rat. I. Cell bodies and nerve trigeminals. Neuroscience, 3: 861–943.
  • 19. Ng YK, Wong WC, Ling EA (1993) A qualitative and quantitative study of substance-P-immunocytochemistry of the trigeminal ganglion in the monkey, Anat Embryol, 188: 53–61.
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  • 21. Pierce J (1985) An immunocytochemical and quantitative examination of dorsal root ganglion neuronal subpopulation. J Neurosci, 5: 2051–2059.
  • 22. Salt TE, Hill RG (1983) Neurotransmitter candidates of somatosensory primary afferent fibers. Neuroscience, 10: 1083–1103.
  • 23. Quartu M, Floris A, Del Fiacco M (1990) Substance Pand calcitonin gene related peptide-like immunoreactive pericellular baskets in human trigeminal ganglion. Basic Appl Histochem, 34: 177–181.
  • 24. Tuscherer MM, Seybold VS (1985) Immunohistochemical studies of substance P, cholecystokinin-octapeptide and somatostatin in dorsal root ganglia of the rat. Neuroscience, 14: 593–605.

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Bibliografia

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