Analysis of the relationship between hemoglobin-oxygen affinity and lipid peroxidation during fever

• Autorzy: Borisiuk M. V. , Zinchuk V.V.
• Języki publikacji: EN

Abstrakty

EN

Endogenous hyperthermia was induced in rabbits by i.v. pyrogenal administration. Hemoglobin-oxygen affinity and parameters of free radical lipid oxidation in plasma and red blood cells were measured. The content of diene conjugates, malonic dialdehyde and Schiff bases were determined at a pyrogenal dose of 4 minimal pyrogenic doses/kg, and iron-initiated chemiluminescence, catalase activity and a-tocopherol concentration were determined at 6 minimal pyrogenic doses/kg. A rightward shift of the real oxyhemoglobin dissociation curve and activation of lipid peroxidation were observed. Relationships between the parameters measured were analyzed. Decreased hemoglobin-oxygen affinity is considered to be a possible mechanism of activation of free radicals during fever.

Słowa kluczowe

EN

alpha-tocopherol concentration; relationship; iron-initiated chemiluminescence; hemoglobin-oxygen affinity; hyperthermia; fever; lipid peroxidation; oxyhemoglobin dissociation curve; Schiff base

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1995
• Tom: 42
• Numer: 1
• Opis fizyczny: p.69-74,fig.

Twórcy

autor

Borisiuk M. V.

• Grodno Medical Institute, Grodno, Republic of Belarus

autor

Zinchuk V.V.

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