Rola osrodkowych receptorow kappa-opioidoergicznych w aktywnosci mioelektrycznej sciany zoladka owcy

• Autorzy: Kania B F , Wielgosz M.

Warianty tytułu

EN

Role of central kappa-opioid receptors in the myoelectrical spike burst activity of the stomach wall in sheep

• Języki publikacji: PL

Abstrakty

EN

The aim of study was to evaluate the participation of central κ-opioidergic receptors in the modulatory/ inhibitory effect of compound U 50,488H, a highly selective -opioid receptor agonist, on the spike burst activity of the rumen, reticulum and antrum prior to and 10 min after a one-minute i.c.v. infusion of norbinaltorphimine, a competitive κ-opioid receptor antagonist, in conscious sheep. U 50,488H was infused i.c.v. at doses of 0.1, 0.25 and 1.0 µg·kg⁻¹ b.w., norbinaltorphimine at doses 10 times higher. All the doses of U 50,488H infused i.c.v. nonsignificantly changed myoelectrical activity of the wall of the rumen, reticulum and antrum. The effects of U 50,488H were not changed by norbinaltorphimine previously infused at doses of 1.0, 2.5 and 10.0 µg·kg⁻¹ b.w. (i.e. at doses 10 times higher than U 50,488H). The results obtained indicate that central κ-opioid receptors did not participate in any action on myoelectrical activity of forestomachs and antrum in sheep.

Słowa kluczowe

PL

owce; motoryka przewodu pokarmowego; zoladek; motoryka zoladka; aktywnosc mioelektryczna; receptory kappa-opioidoergiczne; agonisci receptorow kappa-opioidoergicznych; antagonisci receptorow kappa-opioidoergicznych; U 50,488H; norbinaltorfimina

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2010
• Tom: 66
• Numer: 03
• Opis fizyczny: s.196-200,rys.,bibliogr.

Twórcy

autor

Kania B F

• Szkola Glowna Gospodarstwa Wiejskiego, ul.Nowoursynowska 159, 02-776 Warszawa

autor

Wielgosz M.

Bibliografia

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