DALDA analogues containing alpha-hydroxymethylamino acids

• Autorzy: Olma A. , Chung N.N. , Schiller P.W. , Zabrocki J.
• Języki publikacji: EN

Abstrakty

EN

To evaluate the role of aromatic amino-acids residues, four analogues of theu-selec­tive opioid peptide agonist DALDA (H-Tyr-D-Arg-Phe-Lys-NH2) containing the amphi­philic, a,a-disubstituted amino acid (R)- or (S)-a-hydroxymethyltyrosine (HmTyr) in position 1 and (R)- or (S)-a-hydroxymethylphenylalanine (Hm3Phe) in position 3 of the peptide sequence were synthesized. Only the [(R)- HmPhe3)]DALDA analogue dis­played full agonistic activity in both the guinea pig ileum and the mouse vas deferens assays and turned out to be a δ receptor-selective opioid agonist.

Słowa kluczowe

EN

opioid peptide; in vitro; amphiphilic amino acid; opioid activity; alpha-hydroxymethylamino acid

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2001
• Tom: 48
• Numer: 4
• Opis fizyczny: p.1121-1124

Twórcy

autor

Olma A.

• Technical University of Lodz, 90-924 Lodz, Poland

autor

Chung N.N.

autor

Schiller P.W.

autor

Zabrocki J.

Bibliografia

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