Biochemical kinetics in changing volumes

• Autorzy: Pawlowski P. H. , Zielenkiewicz P.
• Języki publikacji: EN

Abstrakty

EN

The need of taking into account the change of compartment volume when develop­ing chemical kinetics analysis inside the living cell is discussed. Literature models of a single enzymatic Michaelis-Menten process, glycolytic oscillations, and mitotic cyclin oscillations were tested with appropriate theoretical extension in the direction of volume modification allowance. Linear and exponential type of volume increase regimes were compared. Due to the above, in a growing cell damping of the ampli­tude, phase shift, and time pattern deformation of the metabolic rhythms considered were detected, depending on the volume change character. The perfomed computer simulations allow us to conclude that evolution of the cell volume can be an essential factor of the chemical kinetics in a growing cell. The phe­nomenon of additional metabolite oscillations caused by the periodic cell growth and division was theoretically predicted and mathematically described. Also, the hypoth­esis of the periodized state in the growing cell as the generalization of the steady-state was formulated.

Słowa kluczowe

EN

varying volume; chemical kinetics; biochemical kinetics; cyclin oscillation; glycolytic oscillation

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2004
• Tom: 51
• Numer: 1
• Opis fizyczny: p.231-243,fig.,ref.

Twórcy

autor

Pawlowski P. H.

• Polish Academy of Sciences, A.Pawinskiego 5A, 02-106 Warsaw, Poland

autor

Zielenkiewicz P.

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