Badania wplywu niedoboru estrogenow na poziom manganu w zebach i zuchwie szczurow po owariektomii

• Autorzy: Rahnama M. , Bloniarz J. , Zareba S. , Swiatkowski W.
• Języki publikacji: PL

Abstrakty

PL

Wykonano badania poziomu manganu w zębach i żuchwie szczurów po chirurgicznym usunięciu jajników oraz po zastosowaniu estrogenowej terapii zastępczej u operowanych zwierząt. Niedobór estrogenów u samic po owariektomii spowodował obniżenie się zawartości manganu w analizowanych próbkach, a podawanie 17ß-estradiolu szczurom z usuniętymi jajnikami zapobiegało utracie manganu zarówno z zębów, jak i z żuchwy.

EN

Deficiency of the estrogens occurring after menopause or ovariectomy leads to osteopenia and osteoporosis. It was confirmed by noninvasion examinations of bones - skeleton, maxilla mandible and teeth. Demineralization of the hard tissues were connected with loss of calcium and phosphorus, however the role of microelements is not completely known (for example role of Mn). The aim of the study was an attempt of explanation of manganese behave in the structure of hard tissues of masticatory system when the level of estrogens was decreased. Experiment was realized on Wistar female rats. They were divided into seven following groups: CL - control, SH - sham operated, OV - after ovariectomy, OVO - ovariectomized which administered "oleum pro injectioneOVH1 - OVH3 - ovariectomized which administered 17ß-estradiol in three doses: 1.25 µg, 12.5 µg, 125.0 µg (dose on the rat) twice a week. After ovariectomy the level of manganese in teeth as well as in mandible decreased in compared with control group. Differences were statistically significant. Administration of 17ß- estradiol of ovariectomized female rats caused increase of manganese content inconsiderable. These results may suggest that ovarian estrogens play an important role in mineralization of bones and teeth and in prophylaxis of postmenopausal osteoporosis.

Słowa kluczowe

PL

zeby; mangan; zwierzeta laboratoryjne; niedobor estrogenow; estrogeny; 17-beta-estradiol; szczury; samice; owariektomia; zuchwa; poziom manganu; oznaczanie; terapia estrogenowa zastepcza

EN

tooth; manganese; laboratory animal; estrogen deficiency; estrogen; 17-beta estradiol; rat; female; ovariectomy; mandible; manganese level; determination; estrogen replacement therapy

• Wydawca: -
• Czasopismo: Roczniki Państwowego Zakładu Higieny
• Rocznik: 2003
• Tom: 54
• Numer: 1
• Opis fizyczny: s.33-38,tab.,bibliogr.

Twórcy

autor

Rahnama M.

• Akademia Medyczna, ul.Staszica 4, 20-081 Lublin

autor

Bloniarz J.

autor

Zareba S.

autor

Swiatkowski W.