Selective central activation of somatostatin receptor 2 increases food intake, grooming behavior and rectal temperature in rats

• Autorzy: Stengel A. , Goebel M. , Wang L. , Rivier J. , Kobelt P. , Monnikes H. , Tache Y.
• Języki publikacji: EN

Abstrakty

EN

The consequences of selective activation of brain somatostatin receptor-2 (sst2) were assessed using the sst2 agonist, des-AA1,4-6,11-13-[DPhe2,Aph7(Cbm),DTrP8]-Cbm-SST-Thr-NH2. Food intake (FI) was monitored in ad libitum fed rats chronically implanted with an intracerebroventricular (i.c.v.) cannula. The sst2 agonist injected i.c.v. at 0.1 and 1 µg/rat dose-dependently increased light phase FI from 2 to 6 hours post injection (2.3±0.5 and 7.5±1.2 respectively vs. vehicle: 0.2±0.2 g/300 g bw, P<0.001). Peptide action was reversed by i.c.v. injection of the sst2 antagonist, des-AA1,4-6,11-13-[pNO2-Phe2,DCys3,Tyr7,DAph(Cbm)8]-SST-2Nal-NH2 and not reproduced by intraperitoneal injection (30 µg/rat). The sst2 antagonist alone i.c.v. significantly decreased the cumulative 14-hours dark phase FI by 29.5%. Other behaviors, namely grooming, drinking and locomotor activity were also increased by the sst2 agonist (1 µg/rat, i.c.v.) as monitored during the 2nd hour post injection while gastric emptying of solid food was unaltered. Rectal temperature rose 1 hour after the sst2 agonist (1 µg/rat, i.c.v.) with a maximal response maintained from 1 to 4 hours post injection. These data show that selective activation of the brain sst2 receptor induces a feeding response in the light phase not associated with changes in gastric emptying. The food intake reduction following sst2 receptor blockade suggests a role of this receptor in the orexigenic drive during the dark phase.

Słowa kluczowe

EN

somatostatin; somatostatin receptor-2; behaviour; body temperature; rectal temperature; food intake; gastric emptying; rat; feeding; grooming; intracerebroventricular cannula; pituitary secretion; growth hormone; hypothalamic releasing hormone; brain

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology
• Rocznik: 2010
• Tom: 61
• Numer: 4
• Opis fizyczny: p.399-407,fig.,ref.

Twórcy

autor

Stengel A.

• Center for Neurobiology of Stress, CURE Building 115, Room 117, 11301 Wilshire Blvd., Los Angeles, CA, 90073, USA

autor

Goebel M.

autor

Wang L.

autor

Rivier J.

autor

Kobelt P.

autor

Monnikes H.

autor

Tache Y.

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