Cellular components of the bronchoalveolar lavage correlate with lung function impairment and extrapulmonary involvement markers in active sarcoidosis

• Autorzy: Chorostowska-Wynimko J. , Lesniewska-Radomska D. , Krychniak-Soszka A. , Remiszewski P. , Szopinski J. , Wesolowski S. , Kus J. , Skopinska-Rozewska E.
• Języki publikacji: EN

Abstrakty

EN

Sarcoidosis is a chronic inflammatory multiorgan disease of unknown origin. Our previous study demonstrated a significant correlation between the relative count of nonCD4+, nonCD8+ lymphocytes in bronchoalveolar lavage of active sarcoidosis patients and proangiogenic activity of BAL homogenates. The aim of the present study was to evaluate in a group of 40 patients with active sarcoidosis the possible relationship between the intensity of alveolitis, particularly the nonCD4+, nonCD8+ lymphocyte subset, and other parameters characterizing the level of pulmonary (lung function tests) and extrapulmonary (spleen longitudinal dimension) disease activity. We found that the relative count of nonCD4+, nonCD8+ lymphocytes in BAL correlated positively with spleen size (r=0.50, P<0.01) and negatively with static compliance (r=0.43, P<0.05). We concluded that the lymphocytes belonging to the nonCD4+nonCD8+ subset participate in the inflammatory process in sarcoidosis. However, more detailed phenotypic and functional characteristics of this cellular population are needed.

Słowa kluczowe

EN

lung function; chronic inflammatory multiorgan disease; splenomegaly; lymphocyte; sarcoidosis; patient; bronchoalveolar lavage

• Wydawca: -
• Czasopismo: Journal of Physiology and Pharmacology. Supplement
• Rocznik: 2004
• Tom: 55
• Numer: 3
• Opis fizyczny: p.41-47,fig.,ref.

Twórcy

autor

Chorostowska-Wynimko J.

• National Institute of Tuberculosis and Lung Diseases, 26 Plocka St., 01-138 Warsaw, Poland

autor

Lesniewska-Radomska D.

autor

Krychniak-Soszka A.

autor

Remiszewski P.

autor

Szopinski J.

autor

Wesolowski S.

autor

Kus J.

autor

Skopinska-Rozewska E.