The chaperone-usher pathway of bacterial adhesin biogenesis - from molecular mechanism to strategies of anti-bacterial prevention and modern vaccine design

• Autorzy: Piatek R. , Zalewska B. , Bury K. , Kur J.
• Języki publikacji: EN

Abstrakty

EN

The chaperone-usher system determines the biogenesis of surface-exposed adhesive structures responsible for virulence of many Gram-negative bacteria. Investigations of the last 20 years have resolved the mechanism of this pathway on a structural level for different species of pathogenic bacteria. The purpose of this review is to present the molecular mechanisms of the biogenesis of adhesive structures assembled via the chaperone-usher pathway. The obtained mechanistic data allow one to propose potential strategies of anti-bacterial action. Additionally, the specific properties of the polymeric adhesive structures (pili and fimbriae) of the chaperone-usher system allow their use as effective and safe recombinant vaccines carrying foreign epitopes in thousands of copies on bacterial cell surface.

Słowa kluczowe

EN

adhesion; antibacterial action; Gram-negative bacterium; molecular mechanism; adhesive structure; chaperone-usher system; modern vaccine; vaccine; chaperone-usher pathway; biogenesis; pathogenic bacteria; antibacterial prevention

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2005
• Tom: 52
• Numer: 3
• Opis fizyczny: p.639-646,fig.,ref.

Twórcy

autor

Piatek R.

• Gdansk University of Technology, Gdansk, Poland

autor

Zalewska B.

autor

Bury K.

autor

Kur J.

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