Hematological and antifungal properties of temporin A and a cecropin A-temporin A hybrid

• Autorzy: Wade D. , Silveira A. , Rollins-Smith L. , Bergman T. , Silberring J. , Lankinen H.
• Języki publikacji: EN

Abstrakty

EN

Temporin A (TA) and a cecropin A-temporin A hybrid peptide (CATA) were synthe­sized and assayed for their hemolytic, anticoagulant, and antifungal properties. CATA retains significant antifungal activity, is less hemolytic than TA, and inhibits blood coagulation. These results recommend further studies of the biological activi­ties of CATA.

Słowa kluczowe

EN

hybrid peptide; hematological property; temporin A; hybrid; antifungal property; hemolytic property; fibrinolytic property; hemolysis; coagulation

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2001
• Tom: 48
• Numer: 4
• Opis fizyczny: p.1185-1189

Twórcy

autor

Wade D.

• Helsinki University, FIN-00014 Helsinki, Finland

autor

Silveira A.

autor

Rollins-Smith L.

autor

Bergman T.

autor

Silberring J.

autor

Lankinen H.

Bibliografia

• 1.Simmaco,M., Mignogna, G., Canofeni, S., Miele, R., Mangoni, M.L. & Barra, D. (1996) Eur. J. Biochem. 242, 788-792.
• 2.Mangoni, M.L., Rinaldi, A.C., Di Giulio, A., Mignogna, G., Bozzi, A., Barra, D. & Simmaco, M. (2000) Eur. J. Biochem. 267, 1447-1454.
• 3.Steiner, H., Hultmark, D., Engstrom, C, Bennich, H. & Boman, H.G. (1981) Nature 292, 246-248.
• 4.Andreu, D., Ubach, J., Boman, A., Wahlin, B., Wade, D., Merrifield, R.B. & Boman, H.G. (1992) FEBSLett. 296, 190-194.
• 5.Oh, H., Hedberg, M., Wade, D. & Edlund, C. (2000) Antimicrob. Agents Chemother. 44, 68-72.
• 6.Wade, D., Silberring, J., Soliymani, R., Heikkinen, S., Kilpelainen, I., Lankinen, H. & Kuusela, P. (2000) FEBS Lett. 479, 6-9.
• 7.Nylander,I., Tan-No, K., Winter, A. & Silberring, J. (1995) Life Sci. 57, 123-129.
• 8.Ponti,D., Mignogna, G., Mangoni, M.L., DeBiase, D., Simmaco, M. & Barra, D. (1999) Eur. J. Biochem. 263, 921-927.
• 9.Rollins-Smith,L.A., Doersam, J.K., Longcore, J.E., Taylor, S.K., Shamblin, J.C., Carey, C. & Zasloff, M.A. (2001) Dev. Comp. Immunol. (in press).
• 10.Murray,R.K., Granner, D.K., Mayes, P.A. & Rodwell, V.W. (2000) Harper's Biochemistry25th edn., pp. 868-869, Appleton & Lange, Stamford, Connecticut.
• 11.Boman,H.G. (2000) Immunol Rev. 173, 5-16.
• 12.Wade,D., Andreu, D., Mitchell, S.A., Silveira, A.M., Boman, A., Boman, H.G. & Merrifield, R.B. (1992) Int. J. Pept. Protein Res. 40, 429-436.
• 13.Daszak,P., Berger, L., Cunningham, A.A., Hyatt, A.D., Green, D.E. & Speare, R. (1999) Emerg. Infect. Dis. 5, 735-748.