Wolnorodnikowe mechanizmy biochemicznej obrony zywiciela

• Autorzy: Boczon K , Hadas E.
• Języki publikacji: PL

Abstrakty

EN

The mechanism of intracellular killing of pathogens which involves both oxygen and reactive nitrogen intermediates have been discussed. The attention is focused on inducible nitric oxide synthase which produces NO, a soluble free radical. The role of nitric synthase in the pathogenesis of many parasitic infections has recently been emphasised. The participation of enzymatic and non-enzymatic antioxidants in the pathogenesis of many infections and the role of proteasomes in the process of repair of the oxidetively damaged proteins are also discussed.

Słowa kluczowe

PL

mechanizmy obronne; interakcje zywiciel-pasozyt; biochemia; parazytologia; wolne rodniki; zywiciele

• Wydawca: -
• Czasopismo: Wiadomości Parazytologiczne
• Rocznik: 1998
• Tom: 44
• Numer: 2
• Opis fizyczny: s.169-174, bibliogr.

Twórcy

autor

Boczon K

• Akademia Medyczna, ul.Fredry 10, 61-701 Poznan

autor

Hadas E.

Bibliografia

• BABIOR B. M., KIPNES R. S., CARNUTIE J. T. 1973. Biological defence mechanisms. The production by leukocytes of superoxide, a potential bactericidal agent. J. Clin. Invest. 52: 741-744.
• DARLEY-UUSMAR V., WISEMAN H., HALLIWELL B. 1995. Nitric oxide and oxygen radicals: a question of balance. FEBS 369: 131-135.
• HABER F., WEISS J. 1934. The catalytic decomposition of hydrogen peroxide by iron salts. Proc. R. Soc. Ser. A 147: 332-351.
• HADAŚ E., STANKIEWICZ M. 1996. Strategies of biochemical defence mechanisms of parasites against oxidants and free radicals. Acta Parasit. 41: 1-6.
• HAYASHI S., CHAN C. C., GAZZINELLI R., ROBERGE F. G. 1996. Contribution of nitric oxide to the host parasite equilibrium in Toxoplasmosis. J. Immunol. 156: 1476-1481.
• HOGABOAM C. M., COLLINS S. M., BLENNERHASSETT M. G. 1996. Effects of oral L-NAME during Trichinella spiralis infection in rats. Am. J. Physiol. 271 (2 Pt 1): G338-346.
• KEHRER J. P. 1993. Free radicals as mediators of tissue injury and disease. Toxicology 23: 21-48.
• KHAN I. A., MATSUURA T., FONSEKA S., KASPER L. H. 1996. Production of nitric oxide (NO) is not essential for protection against acute Toxoplasma gondii infection in IRF-1-/- mice. J. Immunol. 156: 636-643.
• KLOTZ F. W., SCHELLER L. F., SEGUIN M. C., KUMAR N., MARLETTA M. A., GREEN S. J., AZAD A. F. 1995. Co-localization of inducible-nitric oxide synthase and Plasmodium berghei in hepatocytes from rats immunized with irradiated sporozoites. Ibid. 154: 3391-3395.
• KOSHLAND D. R., Jr. 1992. The molecule of the year. Science 258: 861.
• KRONCKE K. D., FEHSEL K., KOLB-BACHOFEN V. 1995. Inducible nitric oxide synthase and its product nitric oxide, a small molecule with complex biological activites. Biol. Chem. 376: 327-343.
• ORLOWSKI M., WILK S. 1981. A multicatalytic protease complex, a major extralysosomal proteolytic system. Biochem. 29: 10289-10297.
• PROUDFOOT L., NIKOLAEV A. V., FENG G. J., WEI W. Q., FERGUSON M. A., BRIMACOMBE J. S., LIEW F. Y. 1996. Regulation of expression of nitric oxide synthase and leishmanicidal activity by glycoconjugates of Leishmania lipophosphoglycan in murine macrophages. Proc. Natl Acad. Sci. USA 93: 10984-10989.
• RIVETT A. J., KNECHT E. 1993. Proteasome location. Current Biology 3: 127-129.
• ROTTENBERG M. E., CASTANOS-VELEZE E., DE MESQUITAR R., LAGUARDIA O. G., BIBERFELD P., ORN A. 1996. Intracellular co-localization of Trypanosoma cruzi and inducible nitric oxide synthase (iNOS): evidence for dual pathway of iNOS induction. Europ. J. Immunol. 26: 3203-3213.
• SCHARTON-KERSTEN T. M., YAP G., MAGRAM J., SHERA A. 1997. Inducible nitric oxide is essential for host control of persistent but not acute infection with the intracellular pathogen Toxoplasma gondii. J. Exp. Med. 185: 1261-1273.
• SIES H. 1993. Strategies of antioxidant defence. Europ. J. Biochem. 215: 213-219.
• STENGER S., DONHAUSER N., THURING H., ROLLINGHOFF M., BOGDAN C. 1996. Reactivation of latent leishmaniasis by inhibition of inducible nitric oxide synthase. J. Exp. Med. 183: 1501-1514.
• TSUJI M., MIYAHIRA Y., NUSSENZWEIG R. S., AQUET M., REICHEIL M., ZAYALA A. F. 1995. Development of antimalaria immunity in mice lacking IFN-gamma receptor. J. Immunol. 154: 5538-5544.