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2001 | 10 | 3 |

Tytuł artykułu

Lead and zinc influence on antioxidant enzyme activity and malondialdehyde concentrations

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
The influence of zinc on the activity of antioxidant enzymes in the blood of rats intoxicated with lead was studied. Exposure to lead at the concentration of 500 mg/dm3 for 6 weeks caused a decrease in the activities of SOD, GSH-PX and GR as well as an increase in MDA concentrations in the serum. Zinc at the concentration of 60 mg/dm3 administered for a period of 2 weeks after exposure to cadmium reduced the effects of toxic action of lead leading to a normalization of the activities of SOD and GR in the blood as well as MDA concentration in the serum.

Wydawca

-

Rocznik

Tom

10

Numer

3

Opis fizyczny

p.161-165,ref.

Twórcy

  • Medical University, Mickiewicza 2, 15-222 Bialystok, Poland

Bibliografia

  • 1. KULIKOWSKA E., MONIUSZKO-JAKONIUK.J., MINIUK K., KALUZYNSKI A, Wplyw cynku na redystrybucje olowiu w ustroju szczura narazonego na 500 ppm olowiu. Acta Pol.Toxicol. 2, 148, 1994.
  • 2. KULIKOWSKA E., MONIUSZKO-JAKONIUK J., MINIUK K., The influence of lead after administration of ethanol to rats. Pol.J.Pharmacol.Pharm. 41, 281,1989.
  • 3. SKOCZYNSKA A., Peroksydacja lipidow w toksycznym dziataniu olowiu i kadmu. Med.Pracy 2, 197, 1997.
  • 4. AEBI H.E., Methods of enzymatic analysis. Verlag Chemie 3, 273, 1983.
  • 5. BUEGE J.A, AUST S.D, Methods Enzymol. 52, 302,1978.
  • 6. ELLMAN G.L., Tissue sulfhydryl groups. Arch.Biochem.Biophis. 82, 70, 1959.
  • 7. PINTA M., Absorpcyjna spektrometria atomowa-zastosowanie w analizie chemicznej. PWN, Warszawa, 1990.
  • 8. LICZMANSKA A.E., Toksycznosc tlenu II. Mechanizmy obronne. Postepy Bioch. 4, 293, 1988.
  • 9. MINOTTI G., AUST S.D., The role of iron in oxigen radical mediated lipid peroxidation. Chem.Biol.Interact. 71, 1, 1989.
  • 10. KONO Y., FRIDOWICH I, Superoxide radical inhibitis catalase. J.Biol.Chem. 257, 5751,1982 164 Kulikowska-Karpińska E., Moniuszko-Jakoniuk J.
  • 11. KEHRER J.P., Free radicals as mediators of tissue injury and disease. Critical Rev.Toxicol. 1, 21, 1993.
  • 12. PIGEOLET E., CORBISIER P., HOUBION A., Glutatione peroxidase, superoxide dismutase and catalase inactivation by peroxides and derived free radicals. Mechanism of Ageing and Development 51, 283, 1990.
  • 13. FLOHE L., GUNZLER W.A., Glutathione peroxidase, [in:] Glutathione, ed. G. Thiene, Publishers, Stuttgart 132, 1974.
  • 14. QUINLAN G.I., HALLIWELL B., MOORHOUSE C.P., GUTTERIDGE J.M.C., Action of lead (II) and aluminium (III) ions on iron - stimulated lipid peroxidation in lipo somes, erytrocytes and rat liver microsomal fractions. Biochim. Biophis.Acta 962, 196,1988.
  • 15. GRANGER D.N., Role of xantine oxidase and granulocytes in ischemia reperfusion injury. Am.J.Physiol. 255, H1269, 1988.
  • 16. BETTGER W.J., O'DELL B.L., A critical physiological role of zinc in the structure and function of biomembranes. Life Sci. 28, 1425, 1981.
  • 17. BRAY T.M., BETTGER W.J., The physiological role of zinc as an antioxidant. Free Radical.Biol.Med. 8, 281, 1990.
  • 18. KIHARA S., KUBO M., IKEPA N., YOKOYAMA S., MATSUZAWA Y., TARUI S., YAMAMOTO A., HOSTETLER K.Y., Inhibition of purified human postheparin lipoprotein lipase by beta-adrenergic blockers in vitro. Biochem. Pharmacol. 38, 407, 1989.
  • 19. SKOCZYNSKA A., SMOLIK R., The effect of combined exposure to lead and cadmium on serum lipids and lipid peroxides in rats. Int. J. Occup. Med. Environ. Health. 7, 263, 1994.

Typ dokumentu

Bibliografia

Identyfikatory

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