The goal of the studies was to evaluate the protective value of vaccines against pasteurellosis in rabbits. The vaccines comprised antigens to serotypes 3 and 12 of Pasteurella multocida with two different adjuvants: emulsigen and aluminium hydroxide gel. The two vaccines given subcutaneusly either once or twice at a dose of 1 ml protected rabbits markedly against intranasal infection with the virulent strains of examined serotypes. A substantial efficacy of these vaccines was supported by the occurrence of specific precipitins against somatic antigens of serotypes 3 and 12 present in the sera of immunised rabbits even 5 weeks after vaccination