Hyaluronidase in human somatic tissues and urine: polymorphism and the activity in diseases

• Autorzy: Fiszer-Szafarz B. , Vannier P. , Litynska A. , Zou L. , Czartoryska B. , Tylki-Szymanska A.
• Języki publikacji: EN

Abstrakty

EN

The polymorphism of hyaluronidase (EC 3.2.1.35) (Hyase) was studied on a hyalu- ronan-polyacrylamide gel. Liver, placenta, ovary and breast tissue were found to have 7 active isoforms while leukocytes and platelets 5 and fibroblasts displayed no hyaluronidase activity. In serum, synovial fluid and urine soluble the most acidic forms are present. Desialylation showed that most of the hyaluronidase isoforms differ in the content of sialic acid. In patients with rheumatoid arthritis, hyaluronidase activity in the synovial fluid varied from not detectable to very high. A partial deficiency was demnostrated in sera from some patients with dysostosis multiplex without mucopolysacchariduria. In I-cell disease, hyaluronidase activity in serum was as that in controls.

Słowa kluczowe

EN

disease; polymorphism; hyaluronidase; serum; human somatic tissue; urine; rheumatoid arthritis

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1995
• Tom: 42
• Numer: 1
• Opis fizyczny: p.31-33

Twórcy

autor

Fiszer-Szafarz B.

• Centre Universitaire, 91405 Orsay Cedex, France

autor

Vannier P.

autor

Litynska A.

autor

Zou L.

autor

Czartoryska B.

autor

Tylki-Szymanska A.

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