Mozliwosci i ograniczenia profilaktyki swoistej grypy swin

• Autorzy: Markowska-Daniel I , Kowalczyk A.

Warianty tytułu

EN

Possibilities and limitations of swine influenza prophylaxis

• Języki publikacji: PL

Abstrakty

EN

The aim of the paper was the presentation of the newest information regarding abilities to prevent swine influenza using conventional vaccines and technologically advanced preparations obtained by using genetic engineering. In the 90s most swine influenza isolates were closely related to human influenza virus and therefore the vaccine based on human virus type A, subtype H3N2, was widely used. Due to its subsequently decreased efficacy, resulting from antigenic drift and shift as well as the occurrence of new reasorrtants, a new generation of preparations was elaborated. Induction of natural protection against influenza virus is correlated with non-mutation-dependant antibodies, therefore the use of genes coding conserve proteins for immunoprophylaxis was tested. The use of protein NS1 as a differentiation marker between naturally exposed and vaccinated animals, as well as protein NP as an antigen inducing effective cell-mediated and humoral immunological response were suggested. Much attention was given to the selection of gene carriers like plasmid vectors and recombinant viruses; the mechanism of cross-immunoprotection between SIV subtypes; and the adjuvant function. Currently we have no commercially available new generation vaccine that would be able to guarantee spectacular results of immunization for pig breeders, but we have to underline that pilot studies on animals models have as a goal the development of effective tools for the protection of humans against influenza.

Słowa kluczowe

PL

trzoda chlewna; influenza swin; szczepienia ochronne; profilaktyka; szczepionki genetyczne; profilaktyka swoista; choroby zwierzat; szczepionki rekombinowane

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2007
• Tom: 63
• Numer: 08
• Opis fizyczny: s.891-895,bibliogr.

Twórcy

autor

Markowska-Daniel I

• Panstwowy Instytut Weterynaryjny - Panstwowy Instytut Badawczy, Al.Partyzantow 57, 24-100 Pulawy

autor

Kowalczyk A.

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