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2006 | 62 | 03 |

Tytuł artykułu

Chronotherapy in veterinary medicine

Warianty tytułu

Języki publikacji

EN

Abstrakty

EN
Most clinical variables in animals follow biological rhythms which have a mathematical function defined by cosmic-climatic rhythms. Chronophysiology, chronopathology, chronopharmacology and chronotherapy have common elements but are frequently studied in isolation, thus making it difficult for a global understanding of clinical chronobiology as a unitary and well-defined discipline. The physiological effects of a drug depend not only on its molecular structure but also on the time-pattern of its administration. One of the main reasons for the importance of temporal patterns in drug activity is biological rhythm, and in particular that of the circadian period. These rhythms affect most physiological functions as well as drug metabolism, clearance, and dynamic processes that may alter drug availability and target cell responsiveness in relation to biological time. Chronotherapy studys the optimal level of drug effects and/or the minimizing of its toxicity by timing medications in relation to biological rhythms. This review focuses on medical chronobiology, which is much more technical since it only studies those aspects of clinical chronobiology having a health-care impact on daily practice.

Wydawca

-

Rocznik

Tom

62

Numer

03

Opis fizyczny

p.243-247,fig.,ref.

Twórcy

autor
  • Universita degli Studi di Messina, Polo Universitario SS Annunziata 98168 Messina, Italy
autor
autor

Bibliografia

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  • 6.Goldbete A., Claude D.: Time-patterned drug administration: insights from a modelling approach. Chronobiol. Int. 2002, 19, 157-175.
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  • 9.Koyanagi S.: Optimization of the dosage schedule for sustaining intrinsic biological rhythms. Yakugaku Zasshi. 2003, 123, 789-797.
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  • 11.Martinez-Carpio P. A., Corominas A.: General introduction to clinical chronobiology and the therapeutic manipulation of biological rhythms. Med. Clin. 2004, 123, 230-235.
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  • 13.Piccione G., Castaldo C., Carta S., Caola G.: Study on the circadian rhythmicity of some electrocardiographical parameters in the horse. Rivista S.I.D.I. 1998a, 5, 160-163.
  • 14.Piccione G., Castaldo C., Giudice E., Caola G.: Studio della periodicità circadiana di alcuni parametri elettrocardiografici nella bovina. Proc. 30th Congress of Società Italiana di Buiatria (S.I.B.), Piacenza, Italy 22-24.05.1998b, p. 313-319.
  • 15.Piccione G., Castaldo C., Fazio F., Giudice E., Caola G.: The chronocardiology of the sheep: study of the circadian periodicity of some electrocardiographic parameters. Proc. 7th Congress of Mediterranean Federation for Health and Production of Ruminants (Fe.Me.S.P.Rum.), Santarem, Portugal 22-24.04.1999, p. 407-410.
  • 16.Piccione G., Assenza A., Fazio F., Giudice E., Caola, G.: Different periodicities of some haematological parameters in exercise-loaded athletic horses and sedentary horses. J. Equine Sci. 2001a, 12, 17-23.
  • 17.Piccione G., Assenza A., Attanzio G., Fazio F., Caola G.: Chronophysiology of arterial blood pressure and heart rate in athletic horses. Slovenian Veterinary Research. 2001b, 38, 243-248.
  • 18.Piccione G.: Practical applications of chronobiology in livestock. Proc. Symp. on "Biological Rhythms in Livestock", Messina, Italy 14.10.2002, p. 34-42.
  • 19.Piccione G., Caola G.: Biological rhythm in livestock: a review. J. Vet. Sci. 2002, 3, 145-157.
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  • 29.Reinberg A.: Clinical chronopharmacology, an experimental basis for chronotherapy. Arzneimittelforsch. 1978, 28, 1861-1867.
  • 30.Reinberg A.: Des Rythmes Biologiques à la Chronobiologie. Gauthier-Villars, Paris 1979.
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  • 34.Touitou Y., Touitou C., Bogdan A., Reinberg A., Auzeby A., Beck H., Guillet P.: Differences between young and elderly subjects in seasonal and circadian variations of total plasma proteins and blood volume as reflected by hemoglobin, hematocrit, and erythrocyte counts. Clin. Chem. 1986, 32, 801-804.
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Typ dokumentu

Bibliografia

Identyfikatory

Identyfikator YADDA

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