Phonological and semantic fluencies are mediated by different regions of the prefrontal cortex

• Autorzy: Szatkowska I , Grabowska A. , Szymanska O.
• Języki publikacji: EN

Abstrakty

EN

Verbal phonological and semantic fluencies were investigated in 24 patients with unilateral prefrontal lesions and 10 normal control subjects. Lesions were limited to small areas within either the dorsolateral (Brodmann's area 46/9) or ventromedial (posterior part of the gyrus rectus) cortices. In a phonological fluency task, patients with lesions to the left dorsolateral region were impaired. In semantic fluency, not only the left dorsolateral group but also the two right frontal damaged groups performed worse than the control group. In agreement with previous studies, our results show that the phonological fluency is mediated by the left dorsolateral prefrontal cortex. In contrast to this, performance on the semantic fluency task depends on a wider portion of the prefrontal cortex involving the left and right dorsolateral and the right ventromedial areas.

Słowa kluczowe

EN

task; dorsolateral prefrontal cortex; phonological fluency; hemisphere; semantic fluency; memory; brain lesion; ventromedial prefrontal cortex

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2000
• Tom: 60
• Numer: 4
• Opis fizyczny: p.503-508,fig.

Twórcy

autor

Szatkowska I

• Nencki Institute of Experimental Biology, 3 Pasteur St., 02-093 Warsaw, Poland

autor

Grabowska A.

autor

Szymanska O.

Bibliografia

• Ahola K., Vilkki J., Servo A. (1996) Frontal tests do not detect frontal infractions after ruptured intracranial aneurysm. Brain Cogn. 31: 1-16.
• Alexander M.P., Freeman M. (1984) Amnesia after anterior communicating artery aneurysm rupture. Neurology 34: 752-757.
• Bachevalier J., Meunier M., Lu M.X., Ungerleider L.G. (1997) Thalamic and temporal cortex input to medial prefrontal cor­tex in rhesus monkeys. Exp. Brain Res. 115: 430-444.
• Bachevalier J., Mishkin M. (1986) Visual recognition impair­ment follows ventromedial but not dorsolateral prefrontal lesions in monkeys. Behav. Brain Res. 20: 249-261.
• Beeckmans K., Vancoillie P., Michiels K. (1998) Neuropsy- chological deficits in patients with anterior communicating artery syndrome: a multiple case study. Acta Neurol. Belg. 98: 266-278.
• Birri R., Perret E. (1985) What makes frontal lobe damaged patients fail in card sorting and fluency? European Brain and Behavior Workshop on Clinical Neuropsychology, Zürich.
• Boller F. (1968) Latent aphasias: Right and left "nonaphasic" brain-damaged patients compared. Cortex 4: 245-256.
• Bottger S., Prosiegel M., Steiger H.J., Yassouridis A. (1998) Neurobehavioural disturbances, rehabilitation outcome, and lesion site in patients after rupture and repair of anterior communicating artery aneurysm. J. Neurol. Neurosurg. Psych. 65: 93-102.
• Cardebat D., Demonet J. F., Viallard G., Faure S., Puel M., Celsis P. (1996) Brain functional profiles in formal and se­mantic fluency tasks: a SPECT study in normals. Brain Lang. 52: 305-313.
• Damasio A.R., Tranel D., Damasio H. (1989) Amnesia caused by herpes simplex encephalitis, infarctions of the basal forebrain, Alzheimer's disease and anoxia/ischemia. In: Handbook of neuropsychology (Eds. L.R. Squire and G. Gainotti). Vol 3. Elsevier, Amsterdam. p. 149-166.
• Diamond B.J., DeLuca J., Kelley S.M. (1997) Executive and memory impairments in patients with anterior communi­cating artery aneurysm. Brain Cogn. 35: 340-341.
• Elfgren C. I., Risberg J. (1998) Lateralized frontal blood flow increases during fluency tasks: influence of cognitive strat­egy. Neuropsychologia 36: 505-512.
• Gainotti G., Caltagirone C., Miceli, G. (1979) Semantic disor­ders of auditory language comprehension in right-brain­-damaged patients. J. Psycholing. Res. 8: 13-20.
• Gainotti G., Caltagirone C., Miceli G., Masullo C. (1981) Se­lective impairment of semantic-lexical discrimination in right-brain-damaged patients. In: Cognitive processing in the right hemisphere (Ed. E. Perecman). Academic Press, New York. p. 149-167.
• Hecaen H., AlbertM. (1978) Human neuropsychology. Wiley & Son, New York.
• Janowsky J. S., Shimamura A. P., Kritchevsky M., Squire L. R. (1989) Cognitive impairment following frontal lobe damage and its relevance to human amnesia. Behav. Neurosci.. 103: 548-560.
• Joannette Y., GouletP. (1986) Criterion-specific reduction of verbal fluency in right brain-damaged right-handers. Neuropsychologia 24: 875-879.
• Joannette Y., Goulet P., Le Dorze G. (1988) Impaired word naming in right-brain damaged right-handers: Errors types and time-course analyses. Brain Lang. 34: 54-64.
• Klein D., Milner B., Zatorre R. J., Meyer E., Evans A. C. (1995) The neural substrates underlying word generation: A bilingual functional-imaging study. Proc. Natl. Acad. Sci. USA 92: 2899-2903.
• Laine M. (1988) Correlates of word fluency performance. In: Proceedings of the 3 rd Finnish Conference of Neurolin- uistics (Eds. P. Koivuselka-Sallinen and L. Sarajarvi ). University of Joensuun, Joensuun, p. 43-61.
• Lesser R. (1974) Verbal comprehension in aphasia: an Eng­lish version of three Italian tests. Cortex 10: 247-263.
• Lezak M.D. (1995) Neuropsychological assessment. (3rd ed.) Oxford University Press, New York, Oxford.
• Lindgren M., Hagstadius S., Asbjosson G., Asbjosson P. (1997) Neuropsychological rehabilitation of patients with organic solvent induced chronic toxic encephalopathy. A pilot study. Neuropsychol. Rehabil. 7: 1-22.
• Martin R. C., Loring D. W., Meador K. J., Lee G. P. (1990) The effects of lateralized temporal lobe dysfunction on formal and semantic word fluency. Neuropsychologia 28:823-829.
• Mavaddat N., Sahakian B.J., Hutchinson P.J.A., Kirkpatrick P.J. (1999) Cognition following subarachnoid hemorrhage from anterior communicating artery aneurysm: relation to timing of surgery. J. Neurosurg. 91: 402-407.
• Morecraft RJ, Geula C, Mesulam MM. (1992) Cytoarchitec- ture and neural afferents of orbitofrontal cortex in the brain of the monkey. J. Comp. Neurol. 323: 341-358.
• Owen A.M., Sahakian B.J., Semple J., Polkey Ch.E., Robbins T.W. (1995) Visuo-spatial short-term recognition memory and learning after temporal lobe excisions, frontal lobe ex­cisions or amygdalo-hippocampectomy in man. Neuropsychologia 33: 1-24
• Perret E. (1974) The left frontal lobe of man and the suppres­sion of habitual responses in verbal categorical behaviour. Neuropsychologia 12: 323-330.
• Posner M. I. (1994) Attention: The mechanisms of conscious­ness. (994) Proc. Natl. Acad. Sci. 91: 7398-7403.
• Posner M. I., RothbartM. K. (1998) Attention, self-regulation and consciousness. Phil. Trans. R. Soc. Lond. B 353: 1915-1927.
• PtakR., Schnider A. (1999) Spontaneous confabulations after orbitofrontal damage: The role of temporal context confu­sion and self-monitoring. Neurocase 5: 243-250.
• Ramier A. M., Hécaen H. (1970) Rôle respectif des atteintes frontales et de la latéralisation lésionelle dans les deficits de la "fluence verbale". Rev. Neurol. 123: 17-22.
• Saykin A. J., StafiniakP., Robinson L. J., Flannery K. A., Gur R. C., O'Connor M. J., Sperling M.R. (1995) Language be­fore and after temporal lobectomy: specificity of acute changes and relation to early risk factors. Epilepsia 36: 1071-1077.
• Stuss D. T., Alexander M. P. Hamer L., Palumbo C., Dempster R., Binns M., Levine B., Izukava D. (1998) The effects of focal anterior and posterior brain lesions on ver­bal fluency. J. Int. Neuropsychol. Soc. 4: 265-278.
• ThomasAnterion C., Duthel R., Dirkx E., Koenig O., Baudoin V., Laurent B., Brunon J. (1996) Preservation of procedural memory in 18 patients after surgery of aneurysms of the an­terior communicating artery. Neurochirurgie 42: 54-60.
• Thurstone L. (1938) Primary mental abilities. University of Chicago Press, Chicago.
• Troster A. I., Warmflash V., Osorio I., Paolo A. M., Alexander L. J., Barr, W. B. (1995) The roles of semantic networks and search efficiency in verbal fluency performance in in­tractable temporal lobe epilepsy. Epilepsy Res. 21:19-26.
• Varley R. (1995) Lexical-semantic deficits following right hemisphere damage: evidence from verbal fluency tasks. Eur. J. Disord. Commun. 30: 362-271.
• Voytko M.L. (1985) Cooling orbitofrontal cortex disrupts matching-to-sample and visual discrimination learning in monkey. Physiol. Psychol. 13: 219-229.