EN
Several studies have reported that the pyrethroid are extremely toxic to insects, fishes and other aquatic organisms. These chemicals are carboxylic acid esters with three chirial centers located at carbons 1 and 3 of the cyclopropane ring and at the alpha-carbon of alcohol moiety. All of them are generally recognised as potential neurotoxicants, characterised by low mammalian toxicity. The present study deals with the negative effects of synthetic pyrethroid in mammalian organisms. These insecticides have shown to produce reactive oxygen species and induced oxidative stress in mammalian cells. Numerous studies suggest that pyrethroid insecticides should be able to change enzymes activity and have possible genotoxic activity in mammalian organisms.