Leukemic stem cells: from metabolic pathways and signaling to a new concept of drug resistance targeting

• Autorzy: Styczynski J. , Drewa T.
• Języki publikacji: EN

Abstrakty

EN

Cancer stem cells are a small subset of cancer cells constituting a reservoir of self-sustaining cells with the exclusive ability to self-renew and maintain the tumor. These cells are identified by specific stem cell markers: antigens, molecules and signaling pathways. Transcription factors and molecules associated with oncogenesis, such as NF-κB, Bmi-1, Notch, WNT beta-catenin, Sonic hedgehog and their biochemical pathways, active only in a small minority of cancer cells might play key roles in determining the biology and the overall long-term behavior of a tumor. The molecules and pathways specific for cancer stem cells, which contribute to their drug resistance, are potential targets for new therapeutic strategies.

Słowa kluczowe

PL

cancer stem cell; leukemic stem cell; drug resistance; metabolic pathway; stem cell marker; identification; signalling; new concept; therapy

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 2007
• Tom: 54
• Numer: 4
• Opis fizyczny: p.717-726,fig.,ref.

Twórcy

autor

Styczynski J.

• Collegium Medicum, Nicolaus Copernicus University, M.Curie-Sklodowskiej 9, 85-094 Bydgoszcz, Poland

autor

Drewa T.

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