Potencjalne mozliwosci wykorzystania bakteriofagow w leczeniu zakazen bakteryjnych zwierzat

• Autorzy: Weber-Dabrowska B , Gorski A. , Zimecki M. , Lusiak-Szelachowska M. , Grzeda M. , Lis M. , Miedzybrodzki R. , Fortuna W. , Dubiel A. , Switala-Jelen K. , Boratynski J.

Warianty tytułu

EN

Potential application of bacteriophages in bacterial infections in animals

• Języki publikacji: PL

Abstrakty

EN

Antibiotic-resistant bacterial infections have caused serious therapeutic problem in medicine and veterinary practice. Resistance to antibiotics is currently increasing, which is related to, among other factors, the capability of bacteria to produce specific enzymes rendering them resistant to most available antibiotics. Renewed interest in the possibilities of using bacteriophages, viruses that can attack and destroy bacterial cells, in antibacterial therapy in humans and animals has been observed in many countries. Phage therapy of bacterial infections in humans has been conducted by our Institute since 1980. The most successful results were obtained in cases of meningitis, furunculosis, otitis media, cancer, and septicemia (100% of patients). Experimental phage therapy in animals is provided by many centers. Successful therapeutic and protective phage therapy has been observed in calves, piglets, lambs, chickens and mice. Our results on the phage treatment of colibacterosis in foxes, piglets and balanoposithis in bears have demonstrated its high effectiveness. A study on phage preparates for their use in bovine mastitis is currently underway.

Słowa kluczowe

PL

bakteriofagi; infekcja bakteryjna; choroby bakteryjne; terapia fagowa; leczenie; choroby zwierzat

• Wydawca: -
• Czasopismo: Medycyna Weterynaryjna
• Rocznik: 2006
• Tom: 62
• Numer: 11
• Opis fizyczny: s.1219-1221,bibliogr.

Twórcy

autor

Weber-Dabrowska B

• Instytut Immunologii i Terapii Doswiadczalnej PAN, ul.R.Weigla 12, 53-114 Wroclaw

autor

Gorski A.

autor

Zimecki M.

autor

Lusiak-Szelachowska M.

autor

Grzeda M.

autor

Lis M.

autor

Miedzybrodzki R.

autor

Fortuna W.

autor

Dubiel A.

autor

Switala-Jelen K.

autor

Boratynski J.

Bibliografia

• 1. Ackermann H. W., Dubow M. S.: Viruses of Prokaryotes I. General Properties of Bacteriophages. CRC Press. Boca Raton FL. 1987, 1-172.
• 2. Adesiyun A. A.: Characteristic of Staphylococcus aureus strains isolated from bovine mastitic milk: bacteriophage and antimicrobial agent susceptibility and enterotoxigenicity. J. Vet. Med. B. 1994, 42, 129-139.
• 3. Alisky J., Iczkowski K., Rapoport A., Troitsky N.: Bacteriophage show promise as antimicrobial agents. J. Infect. 1998, 36, 5-15.
• 4. Atterbury R. J., Connerton P. L., Dodd C. E., Rees C. E., Connerton J. F.: Application of host specific bacteriophages to the surface of chicken skin leads to a reduction in recovery of Campylobacter jejuni. Appl. Environ. Microbiol. 2003, 69, 6302-6306.
• 5. Barrow P. A., Lovell M., Berchieri A. Jr.: Use of lytic bacteriophage for control of experimental Escherichia coli septicemia and meningitis in chickens and calves. Clin. Diagn. Lab. Immunol. 1998, 5, 294-298.
• 6. Biswas B., Adhya S., Washard B.: Bacteriophage therapy rescues mice bacteremic from a clinical isolate of vancomycin-resistant Enterococcus faecium. Infect. Immun. 2002, 70, 204-210.
• 7. Dubiel A., Kozdrowski R., Bielas W., Siemieniuch M., Weber-Dąbrowska B., Mulczyk M.: Wpływ swoistych bakteriofagów na właściwości nasienia knurów zakażonych pałeczką ropy błękitnej. Med. Vet. 2005, 4(2), 33-40.
• 8. Dubos R. J., Straus J. H., Pierce C.: The multiplication of bacteriophage in vivo and its protective effect against an experimental infection with Shigella dysenteriae. J. Exp. Med. 1943, 20, 161-168.
• 9. Dzierżanowska D.: Mechanizmy bakteryjnej oporności na chemioterapeutyki oraz znaczenie kliniczne tego zjawiska. Medycyna po Dyplomie, wydanie specjalne wrzesień 1995, 3-15.
• 10. Huff W. E., Huff G. R., Rath N. C., Balong J. M., Donoghue A. M.: Prevention of Escherichia coli infection in broiler chicken with a bacteriophage aerosol spray. Poult. Sci. 2002, 81, 1486-1491.
• 11. Huff W. E., Huff G. R., Rath N. C., Balong J. M., Donoghue A. M.: Evaluation of aerosol spray and intramuscular injection of bacteriophage to treat an Escherichia coli respiratory infection. Poult. Sci. 2003, 82, 1108-1112.
• 12. Kaszubkiewicz Cz., Kucharewicz-Krukowska A., Michalski Z., Bocianowski M., Sołtysiak Z., Durlak J.: Próba zastosowania bakteriofagów w leczeniu kolibakteriozy prosiąt. Medycyna Wet. 1982, 38, 281-282.
• 13. Merril C. R., Biswas B., Carlton R.: Long-circulating bacteriophage as antimicrobial agents. Proc. Natl. Acad. Sci. USA 1996, 93, 3188-3192.
• 14. Smith H. W., Huggins M. B.: Successful treatment of experimental Escherichia coli infection in mice using phage: its general superiority over antibiotics. J. Gen. Microbiol. 1982, 129, 307-318.
• 15. Smith H. W., Huggins M. B.: Effectiveness of phages in treating experimental Escherichia coli diarrhoea in calves piglets and lambs. J. Gen. Microbiol. 1983, 129, 2659-2675.
• 16. Smith H. W., Huggins M. B., Shaw K. M.: Factors infuencing the survival and multiplication of bacteriophages in calves and in their environment. J. Gen. Microbiol. 1987, 133, 1127-1135.
• 17. Sulakvelidze A., Alavidze Z., Morris J. G. Jr.: Bacteriophage therapy. Antimicrob. Agents Chemother. 2001, 45, 649-659.
• 18. Ślopek S., Kucharewicz-Krukowska A., Kotz J., Michalski Z., Sołtysiak Z.: Próba leczenia bakteriofagami kolibakteriozy u lisów. Medycyna Wet. 1979, 34, 672-673.
• 19. Weber-Dąbrowska B., Mulczyk M., Górski A.: Bacteriophage therapy of bacterial infections: an update of our Institute's experience. Arch. Immunol. Ther. Exp. 2000, 48, 547-551.