Mitochondria, oxidative stress, and atioxidant defences

• Autorzy: Lenaz G. , Bovina C. , Formiggini G. , Castelli G.P.
• Języki publikacji: EN

Abstrakty

EN

Mitochondria are strongly involved in production of reactive oxygen species, considered today as the main pathogenic agent of many diseases. A vicious circle of oxidative stress and damage to cellular structures can lead to either cell death by apoptosis or to a cellular energetic decline and ageing. The early involvement of mitochondria in apoptosis includes expression of pro-apoptotic factors, release of cytochrome c from the inter-membrane space and opening of the permeability transition pore: cytochrome c release appears to precede pore opening. The mitochondrial theory of ageing considers somatic mutations (deletions) of mitochondrial DNA induced by oxygen radicals as the primary cause of energy decline; experimentally, Complex I appears to be mostly affected. We have developed the Pasteur effect (enhancement of lactate production by mitochondrial inhibition) as a bio-marker of mitochondrial bioenergetics in human platelets, and found it to be decreased in aged individuals. Cells counteract oxidative stress by antioxidants; among lipophilic antioxidants coenzyme Q is the only one of endogenous biosynthesis; exogenous coenzyme Q, however, may protect cells from oxidative stress in vivo.

Słowa kluczowe

EN

mitochondrion; lactate production; aging; oxidative stress; coenzyme Q; apoptosis; antioxidant defense; platelet

• Wydawca: -
• Czasopismo: Acta Biochimica Polonica
• Rocznik: 1999
• Tom: 46
• Numer: 1
• Opis fizyczny: p.1-21,fig.

Twórcy

autor

Lenaz G.

• Universita di Bologna, Via Irnerio 48, 40126 Bologna, Italy

autor

Bovina C.

autor

Formiggini G.

autor

Castelli G.P.

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