The inhibition of in vivo tumorigenesis of osteosarcoma [OS]-732 cells by antisense human osteopontin RNA

• Autorzy: Liu S -J , Zhang D.-Q. , Sui X.-M. , Zhang L. , Cai Z.-W. , Sun L.-Q. , Liu Y.-J. , Xue Y. , Hu G.-F.
• Języki publikacji: EN

Abstrakty

EN

Osteopontin (OPN) is a secreted, non-collagenous, sialic acid-rich protein which functions by mediating cell-matrix interactions and cellular signaling via binding with integrins and CD44 receptors. An increasing number of studies have shown that OPN plays an important role in controlling cancer progression and metastasis. OPN was found to be expressed in many human cancer types, and in some cases, its over-expression was shown to be directly associated with poor patient prognosis. In vitro cancer cell line and animal model studies have clearly indicated that OPN can function in regulating the cell signaling that ultimately controls the oncogenic potential of various cancers. Previous studies in our laboratory demonstrated that OPN is highly expressed in human osteosarcoma (OS) cell line OS-732. In this study, we successfully reduced the tumorigenecity of OS-732 cells xenotransplanted into nude mice, using the antisense human OPN (hOPN) RNA expression vector.

Słowa kluczowe

EN

osteopontin; osteosarcoma; tumourigenesis; antisense RNA; cell-matrix interaction; cellular signalling; cancer progression; metastasis; human cancer type

• Wydawca: -
• Czasopismo: Cellular and Molecular Biology Letters
• Rocznik: 2008
• Tom: 13
• Numer: 1
• Opis fizyczny: p.11-19,fig.,ref.

Twórcy

autor

Liu S -J

• Chinese Academy of Sciences, Beijing 100080, China

autor

Zhang D.-Q.

autor

Sui X.-M.

autor

Zhang L.

autor

Cai Z.-W.

autor

Sun L.-Q.

autor

Liu Y.-J.

autor

Xue Y.

autor

Hu G.-F.

Bibliografia

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