Regional differences in the vulnerability of substantia nigra dopaminergic neurons in weaver mice

• Autorzy: Marti J , Santa-Cruz M.C. , Molina V. , Serra R. , Bayer S.A. , Ghetti B. , Hervas J.P.
• Języki publikacji: EN

Abstrakty

EN

Vulnerability of midbrain dopaminergic (DA) neurons in the weaver mouse was studied at postnatal (P) days 8 and 90, in chosen coronal levels throughout the anteroposterior (AP) extent of the substantia nigra pars compacta (SNc). Wild-type (+/+) and homozygous weaver (wv/wv) mice used were the offspring of pregnant dams injected in several cases with tritiated thymidine on embryonic days 11-15. DA neurons were identified for their tyrosine hydroxylase immunoreactivity. Data reveal that at P8, the frequency of both +/+ and wv/wv late-generated DA cells increases from rostral to caudal SNc. No apparent DA-cell loss was observed at P8 in the mutant genotype, irrespective of the AP level considered. However, throughout the AP, there was a significant reduction in the number of these neurons at any level in 90-day-old weavers. Comparison of P8 and P90 +/+ SNc suggests that cell death is not a major aspect in the developmental regulation of normal DA neurons, although numerical cell depletion in the postnatal development of weaver SNc probably results from the amplification of a basal cell-death process, which affected all the coronal levels studied.

Słowa kluczowe

EN

mice; mouse; homozygous weaver mice; substantia nigra; tyrosine hydroxylase; thymidine; autoradiography; dopaminergic neuron; vulnerability; central nervous system

• Wydawca: -
• Czasopismo: Acta Neurobiologiae Experimentalis
• Rocznik: 2009
• Tom: 69
• Numer: 2
• Opis fizyczny: p.198-206,fig.,ref.

Twórcy

autor

Marti J

• Antonomous University of Barcelona, Barcelona, Spain

autor

Santa-Cruz M.C.

autor

Molina V.

autor

Serra R.

autor

Bayer S.A.

autor

Ghetti B.

autor

Hervas J.P.

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